Bursting and resonance in cerebellar granule cells (D'Angelo et al. 2001)

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Accession:46839
In this study we report theta-frequency (3-12 Hz) bursting and resonance in rat cerebellar granule cells and show that these neurons express a previously unidentified slow repolarizing K1 current (IK-slow ). Our experimental and modeling results indicate that IK-slow was necessary for both bursting and resonance. See paper for more.
Reference:
1 . D'Angelo E, Nieus T, Maffei A, Armano S, Rossi P, Taglietti V, Fontana A, Naldi G (2001) Theta-frequency bursting and resonance in cerebellar granule cells: experimental evidence and modeling of a slow k+-dependent mechanism. J Neurosci 21:759-70 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Cerebellum interneuron granule GLU cell;
Channel(s): I A; I K; I h; I Calcium; I A, slow;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Bursting; Ion Channel Kinetics; Oscillations;
Implementer(s): D'Angelo, Egidio [dangelo at unipv.it];
Search NeuronDB for information about:  Cerebellum interneuron granule GLU cell; I A; I K; I h; I Calcium; I A, slow;
TITLE Cerebellum Granule Cell Model

COMMENT
	Reference: Theta-Frequency Bursting and Resonance in Cerebellar Granule Cells:Experimental
	Evidence and Modeling of a Slow K+-Dependent Mechanism
	Egidio D'Angelo,Thierry Nieus,Arianna Maffei,Simona Armano,Paola Rossi,Vanni Taglietti,
	Andrea Fontana and Giovanni Naldi
ENDCOMMENT
 
NEURON { 
	SUFFIX GrC_Lkg1 
	NONSPECIFIC_CURRENT il
	RANGE el, gl,i
} 
 
UNITS { 
	(mA) = (milliamp) 
	(mV) = (millivolt) 
} 
 
PARAMETER { 
	v (mV) 
	gl = 5.68e-5 (mho/cm2)
	celsius = 30 (degC)
	el = -58 (mV)
} 

ASSIGNED { 
	il (mA/cm2) 
	i (mA/cm2) 
}
  
BREAKPOINT { 
	il = gl*(v - el) 
	i = il
}