Bursting and resonance in cerebellar granule cells (D'Angelo et al. 2001)

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Accession:46839
In this study we report theta-frequency (3-12 Hz) bursting and resonance in rat cerebellar granule cells and show that these neurons express a previously unidentified slow repolarizing K1 current (IK-slow ). Our experimental and modeling results indicate that IK-slow was necessary for both bursting and resonance. See paper for more.
Reference:
1 . D'Angelo E, Nieus T, Maffei A, Armano S, Rossi P, Taglietti V, Fontana A, Naldi G (2001) Theta-frequency bursting and resonance in cerebellar granule cells: experimental evidence and modeling of a slow k+-dependent mechanism. J Neurosci 21:759-70 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Cerebellum interneuron granule GLU cell;
Channel(s): I A; I K; I h; I Calcium; I A, slow;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Bursting; Ion Channel Kinetics; Oscillations;
Implementer(s): D'Angelo, Egidio [dangelo at unipv.it];
Search NeuronDB for information about:  Cerebellum interneuron granule GLU cell; I A; I K; I h; I Calcium; I A, slow;
objref h1
h1 = new VBox()
h1.intercept(1)
   
xpanel("1")   
xlabel("Conductances")
xvalue("gLeakage","soma.gl_GrC_Lkg1", 1,"", 0, 0 )
xvalue("gGabaA","soma.ggaba_GrC_Lkg2", 1,"", 0, 0 )
xvalue("gNabar","soma.gnabar_GrG_Na", 1,"", 0, 0 )
xvalue("gKVbar","soma.gkbar_GrG_KV", 1,"", 0, 0 )
xvalue("gKAbar","soma.gkbar_GrC_KA", 1,"", 0, 0 )
xvalue("gKirbar","soma.gkbar_GrC_Kir", 1,"", 0, 0 )
xvalue("gKCabar","soma.gkbar_GrC_KCa", 1,"", 0, 0 )
xvalue("gCaHVAbar","soma.gcabar_GrC_CaHVA", 1,"", 0, 0 )
xvalue("gpNabar","soma.gnabar_GrC_pNa", 1,"", 0, 0 )
xvalue("gKSlowbar","soma.gkbar_GrG_KM", 1,"", 0, 0 )
xvalue("gNaresurgent","soma.gnabar_GrG_Nar", 1,"", 0, 0 )
xpanel()

xpanel("2")
xlabel("Calcium parameters")
xvalue("Shell thickness","soma.d_Calc", 1,"", 0, 0 )
xvalue("Initial concentration","soma.cai0_Calc", 1,"", 0, 0 )
xvalue("Removal rate","soma.beta_Calc", 1,"", 0, 0 )
xpanel()

xpanel("3",1)
xbutton("Kinetics...","param1()")
xbutton("Cell...","param3()")

xpanel()

xpanel("3",1)

xmenu("Electrodes...")
xbutton("Step IClamp 1","param5()")
xbutton("Step IClamp 2","param6()")
xbutton("Wave IClamp","param7()")
xmenu()

xpanel()

h1.intercept(0)
h1.map("Granule Cell Model")

proc param1(){
	xopen("grc_xpa2.hoc")
}

proc param3(){
	xopen("grc_xpa3.hoc")
}

proc param5(){
	stim0 = new IClamp(0.5)
	stim0.del = 100 
	stim0.dur = 800 
	stim0.amp = 0.002 
	xopen("grc_xpa6.hoc")
}

proc param6(){
	stim = new IClamp(0.5)
	stim.del = 100
	stim.dur = 800
	stim.amp = 0.006
	xopen("grc_xpa7.hoc")
}

proc param7(){
	sinu = new GrC_Sine(0.5)
	sinu.del = 100
	sinu.dur = 800
	sinu.amp = 0.006
	sinu.freq = 4
	sinu.phase = 0 
	xopen("grc_xpa8.hoc")
}