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Bursting and resonance in cerebellar granule cells (D'Angelo et al. 2001)
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Accession:
46839
In this study we report theta-frequency (3-12 Hz) bursting and resonance in rat cerebellar granule cells and show that these neurons express a previously unidentified slow repolarizing K1 current (IK-slow ). Our experimental and modeling results indicate that IK-slow was necessary for both bursting and resonance. See paper for more.
Reference:
1 .
D'Angelo E, Nieus T, Maffei A, Armano S, Rossi P, Taglietti V, Fontana A, Naldi G (2001) Theta-frequency bursting and resonance in cerebellar granule cells: experimental evidence and modeling of a slow k+-dependent mechanism.
J Neurosci
21
:759-70
[
PubMed
]
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Model Information
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Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Cerebellum interneuron granule GLU cell;
Channel(s):
I A;
I K;
I h;
I Calcium;
I A, slow;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
Model Concept(s):
Bursting;
Ion Channel Kinetics;
Oscillations;
Implementer(s):
D'Angelo, Egidio [dangelo at unipv.it];
Search NeuronDB
for information about:
Cerebellum interneuron granule GLU cell
;
I A
;
I K
;
I h
;
I Calcium
;
I A, slow
;
Download the displayed file
/
GranuleCell
readme.txt
grc_ca.mod
grc_calc.mod
grc_ka.mod
Grc_kca.mod
grc_kir.mod
grc_lkg1.mod
Grc_lkg2.mod
grc_pna.mod
Grc_sine.mod
grg_km.mod
Grg_kv.mod
grg_na.mod
grg_nar.mod
grc.hoc
grc_xpa1.hoc
grc_xpa2.hoc
grc_xpa3.hoc
grc_xpa6.hoc
grc_xpa7.hoc
grc_xpa8.hoc
make.bat
mosinit.hoc
del *.c del *.o del *.dll mknrndll
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