Kinetic NMDA receptor model
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Based on voltage-clamp recordings of NMDA receptor-mediated currents in
nucleated patches of rat neocortical layer 5 pyramidal neurons (Kampa 2004),
this model was fit with AxoGraph directly to experimental recordings in order
to obtain the optimal values for the parameters.
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Demo file shows the behaviour of a kinetic NMDA receptor model reproducing the
data in figure 2 in Kampa et al (2004) J Physiol.
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The NMDA receptor model uses realistic rates of magnesium block and its effects
on channel desensitisation. Presynaptic transmitter release is necessary for
glutamate binding to the receptor.
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Kinetic model from Kampa et al (2004) Kinetics of Mg2+ unblock of NMDA
receptors: implications for spike-timing dependent synaptic plasticity.
In: J Physiol 556.2: pp 337–345.
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Model written by Bjoern Kampa, Canberra, 2004
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