Olfactory bulb granule cell: effects of odor deprivation (Saghatelyan et al 2005)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:50210
The model supports the experimental findings on the effects of postnatal odor deprivation, and shows that a -10mV shift in the Na activation or a reduction in the dendritic length of newborn GC could independently explain the observed increase in excitability.
Reference:
1 . Saghatelyan A, Roux P, Migliore M, Rochefort C, Desmaisons D, Charneau P, Shepherd GM, Lledo PM (2005) Activity-dependent adjustments of the inhibitory network in the olfactory bulb following early postnatal deprivation. Neuron 46:103-16 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Olfactory bulb main mitral GLU cell; Olfactory bulb main interneuron granule MC GABA cell;
Channel(s): I Na,t; I A; I K;
Gap Junctions:
Receptor(s): AMPA; NMDA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Ion Channel Kinetics; Active Dendrites; Influence of Dendritic Geometry; Action Potentials; Olfaction;
Implementer(s): Migliore, Michele [Michele.Migliore at Yale.edu];
Search NeuronDB for information about:  Olfactory bulb main mitral GLU cell; Olfactory bulb main interneuron granule MC GABA cell; AMPA; NMDA; I Na,t; I A; I K; Gaba; Glutamate;
/
saghatelyan
readme.txt
kamt.mod *
kdrmt.mod *
naxn.mod *
nmdanet.mod
gc-occ.hoc
mitral-occ.hoc
modeldb.zip
mosinit.hoc
occlusion.hoc
                            
load_file("nrngui.hoc")
load_file("mitral-occ.hoc")
load_file("gc-occ.hoc")
cvode_active(1)

Vrest = -65
dt = 0.1
celsius=25
tstop=100
tdummy=5
nmdafactor=0.015
threshg=-45
threshm=-30

objref ncigcmt, ncmtgca, ncmtgcb, net, g, b, nil, stim, mt, gc

mt = new Mitral()
gc = new GC()

amp=0
delay=20

b = new VBox()
b.intercept(1)
g = new Graph()
g.size(0,tstop,-70,30)
g.xaxis(1)
g.addvar("gc.somagc.v(0.5)",3,1,2*tstop,0,2)
g.addvar("gc.dend.v(1)",2,1,2*tstop,0,2)
g.addvar("mt.soma.v(0.5)",1,1,2*tstop,0,2)
g.color(1)
g.label(0.1,0.05,"mitral")
g.color(3)
g.label(0.2,0.05,"GC soma")
g.exec_menu("10% Zoom out")
g.color(2)
g.label(0.4,0.05,"GC dend")
g.color(4)
xpanel("",1)
xbutton("control", "control()")
xbutton("short dend", "rundend()")
xbutton("Na shift", "runshift()")
xpanel()
b.intercept(0)
b.map()

access mt.soma
	stim=new IClamp(0.5)
	stim.del=5
	stim.dur=2
	stim.amp=1.5

synstr=8 
inh=10
////////////////// circuit definition  

gc.dend		ncigcmt= new NetCon(&v(1),mt.igp,threshg,0,inh*1e-3) 
mt.secden	ncmtgca= new NetCon(&v(0.1),gc.synmt,threshm,0,synstr*nmdafactor) 
mt.secden	ncmtgcb= new NetCon(&v(0.1),gc.sampa,threshm,0,synstr*1e-3) 

////////////////// end circuit definition

proc init() {
	t=0
	flag=0
	finitialize(Vrest)
        fcurrent()
        forall { 
		v=Vrest
		if (ismembrane("nax")) {e_pas=v+(ina+ik)/g_pas} else {e_pas=v}
	}
	cvode.re_init()
	g.begin()
}

proc advance() {
	fadvance()
	g.plot(t)
	g.flush()
	doNotify()
}

proc control() {
gc.somagc.sh_nax= 15
gc.pridengc.L =500
run()
}

proc runshift() {
gc.somagc.sh_nax= 5
gc.pridengc.L =500
run()
}

proc rundend() {
gc.somagc.sh_nax= 15
gc.pridengc.L =300
run()
}