Tonic neuron in spinal lamina I: prolongation of subthreshold depol. (Prescott and De Koninck 2005)

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Accession:53569
Model demonstrates mechanism whereby two kinetically distinct inward currents act synergistically to prolong subthreshold depolarization. The important currents are a persistent Na current (with fast kinetics) and a persistent Ca current (with slower kinetics). Model also includes a slow K current and transient Ca current, in addition to standard HH currents. Model parameters are set to values used in Fig. 8A. Simulation shows prolonged depolarizations in response to two brief stimuli.
Reference:
1 . Prescott SA, De Koninck Y (2005) Integration time in a subset of spinal lamina I neurons is lengthened by sodium and calcium currents acting synergistically to prolong subthreshold depolarization. J Neurosci 25:4743-54 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Spinal cord lamina I neuron;
Channel(s): I Na,p; I K,Ca; I Calcium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Nociception; Delay; Calcium dynamics;
Implementer(s): Prescott, Steven [steve.prescott at sickkids.ca]];
Search NeuronDB for information about:  I Na,p; I K,Ca; I Calcium;
Files displayed below are from the implementation
load_file("nrngui.hoc")
load_file("toniclamina1neuron.ses")

// modify from original simulation for faster demo:

steps_per_ms=1
dt=1

// original settings were
// steps_per_ms=10
// dt =0.01