NEUROFIT: fitting HH models to voltage clamp data (Willms 2002)

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Publicly available software for accurate fitting of Hodgkin-Huxley models to voltage-clamp data... The set of parameter values for the model determined by this software yield current traces that are substantially closer to the observed data than those determined from the usual fitting method. This improvement is due to the fact that the software fits all of the parameters simultaneously utilizing all of the data rather than fitting steady-state and time constant parameters disjointly using peak currents and portions of the rising and falling phases... The software also incorporates a linear pre-estimation procedure to help in determining reasonable initial values for the full non-linear algorithm. See references for details and more.
1 . Willms AR, Baro DJ, Harris-Warrick RM, Guckenheimer J (1999) An improved parameter estimation method for Hodgkin-Huxley models. J Comput Neurosci 6:145-68 [PubMed]
2 . Willms AR (2002) NEUROFIT: software for fitting Hodgkin-Huxley models to voltage-clamp data. J Neurosci Methods 121:139-50 [PubMed]
3 . Tóth TI, Crunelli V (1995) A numerical procedure to estimate kinetic and steady-state characteristics of inactivating ionic currents. J Neurosci Methods 63:1-12 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type:
Brain Region(s)/Organism:
Cell Type(s):
Gap Junctions:
Simulation Environment: FORTRAN; C or C++ program (web link to model);
Model Concept(s): Parameter Fitting; Methods;
Implementer(s): Willms, Allan [AWillms at]; Kuo, Howie ; Ewing, Greg;