Breakdown of accmmodation in nerve: a possible role for INAp (Hennings et al 2005)

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Accession:55749
The present modeling study suggests that persistent, low-threshold, rapidly activating sodium currents have a key role in breakdown of accommodation, and that breakdown of accommodation can be used as a tool for studying persistent sodium current under normal and pathological conditions. See paper for more and details.
Reference:
1 . Hennings K, Arendt-Nielsen L, Andersen OK (2005) Breakdown of accommodation in nerve: a possible role for persistent sodium current. Theor Biol Med Model 2:16 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Spinal cord lumbar motor neuron alpha ACh cell; Myelinated neuron;
Channel(s): I Na,p; I Na,t; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: MATLAB;
Model Concept(s): Action Potential Initiation; Action Potentials; Pathophysiology; Electrotonus;
Implementer(s): Hennings, Kristian [krist at hst.auc.dk];
Search NeuronDB for information about:  Spinal cord lumbar motor neuron alpha ACh cell; I Na,p; I Na,t; I K;
function [I,TIME] = SDcurveGEN(T,M,S)
%SDCurveGEN this function simulates the strength-duration curve
%   [I] = SDcurve(T,M,S) this function estimate the excitation thresholds
%   [I] for rectangular pulses with durations [T], for the model [M] and the
%   stimulus [S]

%Create the parameters for the excitation function
Imax = 10e-9; Nmsi = 5; Itol = 0.0001e-9; noAP = 1; 

fprintf('PROCESS [');
tic
for n = 1:length(T)
    S(3) = T(n);
    I(n) = excitation(Imax,Nmsi,Itol,noAP,[0 T(n)+1e-3],M,S);
    fprintf('.');
end
TIME = toc;
fprintf('] : %.2fs\n',TIME);