Dendritic Na inactivation drives a decrease in ISI (Fernandez et al 2005)

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Accession:59480
We use a combination of dynamical analysis and electrophysiological recordings to demonstrate that spike broadening in dendrites is primarily caused by a cumulative inactivation of dendritic Na(+) current. We further show that a reduction in dendritic Na(+) current increases excitability by decreasing the interspike interval (ISI) and promoting burst firing.
Reference:
1 . Fernandez FR, Mehaffey WH, Turner RW (2005) Dendritic Na+ current inactivation can increase cell excitability by delaying a somatic depolarizing afterpotential. J Neurophysiol 94:3836-48 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): ELL pyramidal cell;
Channel(s): I Na,t; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: MATLAB;
Model Concept(s): Activity Patterns; Dendritic Action Potentials; Active Dendrites;
Implementer(s): Fernandez FR [ffernand at ucalgary.ca]; Mehaffey WH ;
Search NeuronDB for information about:  I Na,t; I K;
 
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na_excit
                            
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