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Dendritic Na inactivation drives a decrease in ISI (Fernandez et al 2005)
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We use a combination of dynamical analysis and electrophysiological recordings to demonstrate that spike broadening in dendrites is primarily caused by a cumulative inactivation of dendritic Na(+) current. We further show that a reduction in dendritic Na(+) current increases excitability by decreasing the interspike interval (ISI) and promoting burst firing.
Fernandez FR, Mehaffey WH, Turner RW (2005) Dendritic Na+ current inactivation can increase cell excitability by delaying a somatic depolarizing afterpotential.
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Neuron or other electrically excitable cell;
ELL pyramidal cell;
Dendritic Action Potentials;
Fernandez FR [ffernand at ucalgary.ca];
Mehaffey WH ;
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