Tonic firing in substantia gelatinosa neurons (Melnick et al 2004)

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Accession:62285
Ionic conductances underlying excitability in tonically firing neurons (TFNs) from substantia gelatinosa (SG) were studied by the patch-clamp method in rat spinal cord slices. ... Suppression of Ca2+ and KCA currents ... did not abolish the basic pattern of tonic firing, indicating that it was generated by voltage-gated Na+ and K+ currents. ... on the basis of present data, we created a model of TFN and showed that Na+ and KDR currents are sufficient to generate a basic pattern of tonic firing. It is concluded that the balanced contribution of all ionic conductances described here is important for generation and modulation of tonic firing in SG neurons. See paper for more and details.
Reference:
1 . Melnick IV, Santos SF, Szokol K, Szûcs P, Safronov BV (2004) Ionic basis of tonic firing in spinal substantia gelatinosa neurons of rat. J Neurophysiol 91:646-55 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s): I Na,t; I A; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns;
Implementer(s): Safronov, Boris [safronov at ibmc.up.pt];
Search NeuronDB for information about:  I Na,t; I A; I K;
/*
5/17/2017  Revised by N.T. Carnevale for the sake of conceptual clarity
and to facilitate attributed reuse.
In this version, the reference temperature is 23 deg C
and the value assigned to celsius is the actual operating temperature
in degrees celsius.
*/

objectvar save_window_, rvp_
objectvar scene_vector_[4]
objectvar ocbox_, ocbox_list_, scene_, scene_list_
{ocbox_list_ = new List()  scene_list_ = new List()}

//Begin I/V Clamp Electrode
{
load_file("electrod.hoc")
}
{
ocbox_=new Electrode(0)
execute("can_locate=1 sec=\"soma\" xloc=0.55 locate(0)", ocbox_)
execute("vc.dur[0]=20 vc.amp[0]=-80", ocbox_)
execute("vc.dur[1]=200 vc.amp[1]=60", ocbox_)
execute("vc.dur[2]=10 vc.amp[2]=-80", ocbox_)
execute("stim.del=50 stim.dur=500 stim.amp=0.01", ocbox_)
execute("vcsteps=5", ocbox_)
execute("samp=stim.amp  store_vclamp() glyph()", ocbox_)
ocbox_ = ocbox_.v1
ocbox_.map("I/V Clamp Electrode", 921, 13, 249.75, 459.75)
}
objref ocbox_
//End I/V Clamp Electrode

{
xpanel("NEURON Main Panel", 0)
xcheckbox("Quiet",&stdrun_quiet,"")
realtime = 6
xvalue("Real Time","realtime", 0,"", 0, 1 )
// celsius = 6.3
celsius = 23 // actual operating temperature
xvalue("celsius","celsius", 1,"", 0, 1 )
global_ra = 80
xvalue("Axial Resistivity","global_ra", 1,"set_ra()", 1, 1 )
xbutton("RunControl","nrncontrolmenu()")
xmenu("New Graph", 0)
xbutton("Voltage axis","newPlotV()")
xbutton("Current axis","newPlotI()")
xbutton("State axis","newPlotS()")
xbutton("Shape plot","newshapeplot()")
xbutton("Vector movie","newvectorplot()")
xbutton("Phase Plane","newphaseplane()")
xbutton("Grapher","load_proc(\"makegrapher\") makegrapher()")
xmenu()
xmenu("Point Processes", 0)
xmenu("Managers", 0)
xbutton("Point Manager","load_template(\"PointProcessManager\") makeppm()")
xbutton("Point Group","load_template(\"PointProcessGroupManager\") makeppgm()")
xbutton("Electrode","load_proc(\"makeelectrode\") makeelectrode()")
xmenu()
xmenu("Viewers", 0)
xmenu("PointProcesses", 0)
xbutton("IClamp","makePointBrowser(\"IClamp\")")
xbutton("AlphaSynapse","makePointBrowser(\"AlphaSynapse\")")
xbutton("SEClamp","makePointBrowser(\"SEClamp\")")
xbutton("VClamp","makePointBrowser(\"VClamp\")")
xbutton("APCount","makePointBrowser(\"APCount\")")
xmenu()
xmenu()
xmenu()
xmenu("Distributed Mechanisms", 0)
xmenu("Managers", 0)
xbutton("Inserter","load_template(\"Inserter\") makeinserter()")
xbutton("Homogeneous Spec","load_proc(\"makeshowmechanism\") makeshowmechanism()")
xmenu()
xmenu("Viewers", 0)
xbutton("Shape Name","load_template(\"MenuExplore\") makeMenuExplore()")
xbutton("Name Values","nrnallsectionmenu()")
xmenu("Mechanisms (Globals)", 0)
xbutton("na_ion","nrnglobalmechmenu(\"na_ion\")")
xbutton("k_ion","nrnglobalmechmenu(\"k_ion\")")
xbutton("hh","nrnglobalmechmenu(\"hh\")")
xmenu()
xmenu()
xmenu()
xmenu("Miscellaneous", 0)
xmenu("Clipboard", 0)
xbutton("Save to File","load_proc(\"clipboard_save\") clipboard_save()")
xbutton("Retrieve from File","load_proc(\"clipboard_retrieve\") clipboard_retrieve()")
xmenu()
xbutton("Family","load_template(\"Family\") makeFamily()")
xbutton("Parameterized Function","load_template(\"FunctionFitter\") makefitter()")
xbutton("Run Fitter","load_template(\"RunFitter\") makerunfitter()")
xmenu("Impedance", 0)
xbutton("Frequency","load_template(\"ImpedanceRatio\") makeImpRatio()")
xbutton("Path","load_template(\"Impx\") makeImpx()")
xbutton("log(A) vs x","load_template(\"LogAvsX\") makelogax()")
xbutton("Shape","load_template(\"ImpShape\") makeImpShape()")
xmenu()
xmenu()
xpanel(3,318)
}
{
xpanel("RunControl", 0)
v_init = -70
xvalue("Init","v_init", 1,"stdinit()", 1, 1 )
xbutton("Init & Run","run()")
xbutton("Stop","stoprun=1")
runStopAt = 5
xvalue("Continue til","runStopAt", 1,"{continuerun(runStopAt) stoprun=1}", 1, 1 )
runStopIn = 1
xvalue("Continue for","runStopIn", 1,"{continuerun(t + runStopIn) stoprun=1}", 1, 1 )
xbutton("Single Step","steprun()")
t = 700
xvalue("t","t", 2 )
tstop = 700
xvalue("Tstop","tstop", 1,"tstop_changed()", 0, 1 )
dt = 0.05
xvalue("dt","dt", 1,"setdt()", 0, 1 )
steps_per_ms = 20
xvalue("Points plotted/ms","steps_per_ms", 1,"setdt()", 0, 1 )
xpanel(601,16)
}
{
save_window_ = new Graph(0)
save_window_.size(0,700,-90,50)
scene_vector_[3] = save_window_
{save_window_.view(0, -90, 700, 140, 158, 10, 318.75, 265)}
graphList[0].append(save_window_)
save_window_.save_name("graphList[0].")
save_window_.addexpr("soma.v(0.5)", 1, 1, 0.46369, 0.933666, 2)
}
{
xpanel("soma(0 - 1) (Parameters)", 0)
xlabel("soma(0 - 1) (Parameters)")
xlabel("nseg = 10")
soma.L = 10
xvalue("L","soma.L", 1,"define_shape()", 0, 0 )
soma.cm = 1
xvalue("cm","soma.cm", 1,"", 0, 0 )
soma.diam = 10
xvalue("diam","soma.diam", 1,"", 0, 0 )
soma.gnabar_B_Na = 0.008
xvalue("gnabar_B_Na","soma.gnabar_B_Na", 1,"", 0, 0 )
soma.ena = 60
xvalue("ena","soma.ena", 1,"", 0, 0 )
soma.g_pas = 1.1e-05
xvalue("g_pas","soma.g_pas", 1,"", 0, 0 )
soma.e_pas = -70
xvalue("e_pas","soma.e_pas", 1,"", 0, 0 )
soma.gkbar_KDRI = 0.0043
xvalue("gkbar_KDRI","soma.gkbar_KDRI", 1,"", 0, 0 )
soma.ek = -84
xvalue("ek","soma.ek", 1,"", 0, 0 )
xpanel(303,567)
}
{
xpanel("dend[0](0 - 1) (Parameters)", 0)
xlabel("dend[0](0 - 1) (Parameters)")
xlabel("nseg = 50")
dend[0].L = 1371
xvalue("L","dend[0].L", 1,"define_shape()", 0, 0 )
dend[0].cm = 1
xvalue("cm","dend[0].cm", 1,"", 0, 0 )
dend[0].diam = 1.4
xvalue("diam","dend[0].diam", 1,"", 0, 0 )
dend[0].gnabar_SS = 0
xvalue("gnabar_SS","dend[0].gnabar_SS", 1,"", 0, 0 )
dend[0].ena = 60
xvalue("ena","dend[0].ena", 1,"", 0, 0 )
dend[0].g_pas = 1.1e-05
xvalue("g_pas","dend[0].g_pas", 1,"", 0, 0 )
dend[0].e_pas = -70
xvalue("e_pas","dend[0].e_pas", 1,"", 0, 0 )
dend[0].gkbar_KDRI = 0.034
xvalue("gkbar_KDRI","dend[0].gkbar_KDRI", 1,"", 0, 0 )
dend[0].ek = -84
xvalue("ek","dend[0].ek", 1,"", 0, 0 )
xpanel(9,562)
}
{
xpanel("hillock(0 - 1) (Parameters)", 0)
xlabel("hillock(0 - 1) (Parameters)")
xlabel("nseg = 30")
hillock.L = 30
xvalue("L","hillock.L", 1,"define_shape()", 0, 0 )
hillock.cm = 1
xvalue("cm","hillock.cm", 1,"", 0, 0 )
xlabel("diam is not constant")
hillock.gnabar_B_Na = 1.8
xvalue("gnabar_B_Na","hillock.gnabar_B_Na", 1,"", 0, 0 )
hillock.ena = 60
xvalue("ena","hillock.ena", 1,"", 0, 0 )
hillock.g_pas = 1.1e-05
xvalue("g_pas","hillock.g_pas", 1,"", 0, 0 )
hillock.e_pas = -70
xvalue("e_pas","hillock.e_pas", 1,"", 0, 0 )
hillock.gkbar_KDRI = 0.076
xvalue("gkbar_KDRI","hillock.gkbar_KDRI", 1,"", 0, 0 )
hillock.ek = -84
xvalue("ek","hillock.ek", 1,"", 0, 0 )
xpanel(628,567)
}
{
xpanel("axon(0 - 1) (Parameters)", 0)
xlabel("axon(0 - 1) (Parameters)")
xlabel("nseg = 50")
axon.L = 0.001
xvalue("L","axon.L", 1,"define_shape()", 0, 0 )
axon.cm = 1
xvalue("cm","axon.cm", 1,"", 0, 0 )
axon.diam = 0.001
xvalue("diam","axon.diam", 1,"", 0, 0 )
axon.gnabar_B_Na = 0
xvalue("gnabar_B_Na","axon.gnabar_B_Na", 1,"", 0, 0 )
axon.ena = 60
xvalue("ena","axon.ena", 1,"", 0, 0 )
axon.g_pas = 0
xvalue("g_pas","axon.g_pas", 1,"", 0, 0 )
axon.e_pas = -70
xvalue("e_pas","axon.e_pas", 1,"", 0, 0 )
axon.gkbar_KDRI = 0
xvalue("gkbar_KDRI","axon.gkbar_KDRI", 1,"", 0, 0 )
axon.ek = -84
xvalue("ek","axon.ek", 1,"", 0, 0 )
xpanel(949,566)
}
objectvar scene_vector_[1]
{doNotify()}