Kv4.3, Kv1.4 encoded K(+) channel in heart cells (Greenstein et al 2000) (XPP)

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Accession:62287
A model of canine I:(to1) (the Ca(2+)-independent transient outward current) is formulated as the combination of Kv4.3 and Kv1.4 currents and is incorporated into an existing canine ventricular myocyte model. Simulations demonstrate strong coupling between L-type Ca(2+) current and I:(Kv4.3) and predict a bimodal relationship between I:(Kv4.3) density and APD whereby perturbations in I:(Kv4.3) density may produce either prolongation or shortening of APD, depending on baseline I:(to1) current level. The model files were submitted by: Dr. Sheng-Nan Wu, Dr. Ruey J. Sung, Ya-Jean Wang and Jiun-Shian Wu e-mail: snwu@mail.ncku.edu.tw
Reference:
1 . Greenstein JL, Wu R, Po S, Tomaselli GF, Winslow RL (2000) Role of the calcium-independent transient outward current I(to1) in shaping action potential morphology and duration. Circ Res 87:1026-33 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Channel/Receptor;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s): I A;
Gap Junctions:
Receptor(s):
Gene(s): Kv4.3 KCND3; Kv1.4 KCNA4;
Transmitter(s):
Simulation Environment: XPP;
Model Concept(s): Ion Channel Kinetics; Heart disease;
Implementer(s): Wu, Sheng-Nan [snwu at mail.ncku.edu.tw]; Wu, Jiun-Shian [coolneon at gmail.com]; Sung, Ruey J ; Wang, Ya-Jean ;
Search NeuronDB for information about:  I A;
 
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