Dynamical model of olfactory bulb mitral cell (Rubin, Cleland 2006)

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Accession:64296
This four-compartment mitral cell exhibits endogenous subthreshold oscillations, phase resetting, and evoked spike phasing properties as described in electrophysiological studies of mitral cells. It is derived from the prior work of Davison et al (2000) and Bhalla and Bower (1993). See readme.txt for details.
Reference:
1 . Rubin DB, Cleland TA (2006) Dynamical mechanisms of odor processing in olfactory bulb mitral cells. J Neurophysiol 96:555-68 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Olfactory bulb main mitral GLU cell;
Channel(s): I Na,p; I Na,t; I L high threshold; I A; I K; I K,leak; I h; I K,Ca; I Sodium; I Calcium; I Potassium; I A, slow;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Bursting; Temporal Pattern Generation; Oscillations; Synchronization; Simplified Models; Delay; Olfaction;
Implementer(s): Rubin, Daniel B ;
Search NeuronDB for information about:  Olfactory bulb main mitral GLU cell; I Na,p; I Na,t; I L high threshold; I A; I K; I K,leak; I h; I K,Ca; I Sodium; I Calcium; I Potassium; I A, slow;
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mitral
readme.txt *
cadecay.mod *
Ih.mod *
INaP.mod
kA.mod
kca3.mod
kfasttab.mod *
kO.mod *
kslowtab.mod *
lcafixed.mod *
nafast.mod
kfast_k.inf *
kfast_k.tau *
kfast_n.inf *
kfast_n.tau *
kslow_k.inf *
kslow_k.tau *
kslow_n.inf *
kslow_n.tau *
mitral.hoc
mosinit.hoc *
tabchannels.hoc *
                            
TITLE Calcium decay
: Implemented in Rubin and Cleland (2006) J Neurophysiology
: written by Andrew Davison et al (2000) Brain Res Bulletin
: as described in Bhalla and Bower (1993) J Neurophysiology 69:1948-1983 (1993)
: partially based on cadecay.mod by Alain Destexhe, Salk Institute 1995.

INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms) }

NEURON{
	SUFFIX cad
	USEION ca READ ica, cai WRITE cai
	RANGE ica, channel_flow, depth, B
	GLOBAL cai, tau, cainf
}

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)
	(molar) = (1/liter)
	(mM) = (millimolar)
	(um) = (micron)
}

CONSTANT {
      FARADAY = 96154 (coul)
	:FARADAY = 93149 (coul)		: moles do not appear in units
						: note this value is chosen to fit with
						: Genesis
}

PARAMETER {
	dt (ms)
	depth = 1 	(um)		: shell within which cai is calculated
					: to match Bhalla and Bower 1993 set
					: depth = diam/4 for each compartment
	tau = 1e-5 	(ms)		: cai decay constant
	cainf = 1e-5	(mM)		: baseline calcium concentration
	ica		(mA/cm2)
}

STATE {
	cai		(mM)
}

INITIAL {
	cai = cainf
}

ASSIGNED {
	channel_flow	(mM/ms)
	B		(mM cm2/ms/mA)
}

BREAKPOINT {
	SOLVE state METHOD cnexp
}

DERIVATIVE state {
	B = -(1e4)/(2*FARADAY*depth)
	channel_flow = B*ica
	if (channel_flow <= 0.0 ) { channel_flow = 0.0 }	: one way flow in channel
	cai' = channel_flow  - (cai - cainf)/tau
}