CA1 pyramidal neuron synaptic integration (Li and Ascoli 2006, 2008)

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Accession:71312
The model shows how different input patterns (irregular & asynchronous, irregular & synchronous, regular & asynchronous, regular & synchronous) affect the neuron's output rate when 1000 synapses are distributed in the proximal apical dendritic tree of a hippocampus CA1 pyramidal neuron.
Reference:
1 . Li X, Ascoli GA (2006) Computational simulation of the input-output relationship in hippocampal pyramidal cells J of Comput Neurosci 21(2):191-209 [PubMed]
2 . Li X, Ascoli GA (2008) Effects of synaptic synchrony on the neuronal input-output relationship. Neural Comput 20:1717-31 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal cell;
Channel(s): I Na,t; I A; I K; I h;
Gap Junctions:
Receptor(s): AMPA; NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Detailed Neuronal Models; Synaptic Integration;
Implementer(s): Li, Xiaoshen [xsli2 at yahoo.com];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell; AMPA; NMDA; I Na,t; I A; I K; I h;
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xiaoshenli
readme.txt
distr.mod *
h.mod *
kadist.mod *
kaprox.mod *
kdrca1.mod *
na3n.mod *
naxn.mod *
c20466.hoc
createNewSyn.hoc
createNewSyn2.hoc
exec.hoc
fig4A.hoc
fixnseg.hoc *
ModelTypeC.hoc
ModelTypeI.hoc
mosinit.hoc
NregNsyn.hoc
Nregsyn.hoc
regNsyn.hoc *
                            
TITLE ...just to store peak membrane voltage
: M.Migliore June 2001

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)

}

PARAMETER {
	v (mV)
}


NEURON {
	SUFFIX ds
        RANGE vmax
}

ASSIGNED {
	vmax
}

INITIAL {
	vmax=v
}


BREAKPOINT {
	if (v>vmax) {vmax=v}
}