Cerebellar purkinje cell (De Schutter and Bower 1994)

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Accession:7176
Tutorial simulation of a cerebellar Purkinje cell. This tutorial is based upon a GENESIS simulation of a cerebellar Purkinje cell, modeled and fine-tuned by Erik de Schutter. The tutorial assumes that you have a basic knowledge of the Purkinje cell and its synaptic inputs. It gives visual insight in how different properties as concentrations and channel conductances vary and interact within a real Purkinje cell.
Reference:
1 . De Schutter E, Bower JM (1994) An active membrane model of the cerebellar Purkinje cell. I. Simulation of current clamps in slice. J Neurophysiol 71:375-400 [PubMed]
2 . De Schutter E, Bower JM (1994) An active membrane model of the cerebellar Purkinje cell II. Simulation of synaptic responses. J Neurophysiol 71:401-19 [PubMed]
3 . Staub C, De Schutter E, Knöpfel T (1994) Voltage-imaging and simulation of effects of voltage- and agonist-activated conductances on soma-dendritic voltage coupling in cerebellar Purkinje cells. J Comput Neurosci 1:301-11 [PubMed]
4 . De Schutter E, Bower JM (1994) Simulated responses of cerebellar Purkinje cells are independent of the dendritic location of granule cell synaptic inputs. Proc Natl Acad Sci U S A 91:4736-40 [PubMed]
5 . De Schutter E (1998) Dendritic voltage and calcium-gated channels amplify the variability of postsynaptic responses in a Purkinje cell model. J Neurophysiol 80:504-19 [PubMed]
6 . Jaeger D, De Schutter E, Bower JM (1997) The role of synaptic and voltage-gated currents in the control of Purkinje cell spiking: a modeling study. J Neurosci 17:91-106 [PubMed]
7 . de Schutter E (1994) Modelling the cerebellar Purkinje cell: experiments in computo. Prog Brain Res 102:427-41 [PubMed]
8 . De Schutter E (1997) A new functional role for cerebellar long-term depression. Prog Brain Res 114:529-42 [PubMed]
9 . Steuber V, Mittmann W, Hoebeek FE, Silver RA, De Zeeuw CI, Häusser M, De Schutter E (2007) Cerebellar LTD and pattern recognition by Purkinje cells. Neuron 54:121-36 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Cerebellum Purkinje GABA cell;
Channel(s): I Na,p; I Na,t; I T low threshold; I p,q; I A; I K; I M; I K,Ca; I Sodium; I Calcium; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Activity Patterns; Dendritic Action Potentials; Active Dendrites; Detailed Neuronal Models; Tutorial/Teaching; Synaptic Integration;
Implementer(s): Cornelis, Hugo [hugo at bbf.uia.ac.be]; Airong, Dong [tard at fimmu.com];
Search NeuronDB for information about:  Cerebellum Purkinje GABA cell; I Na,p; I Na,t; I T low threshold; I p,q; I A; I K; I M; I K,Ca; I Sodium; I Calcium; I Potassium; 
$Id: README 1.2.1.3 Sat, 13 May 2000 12:14:21 +0200 hugo $

README file for the Tutorial simulation of a cerebellar Purkinje cell

This tutorial is based upon a GENESIS simulation of a cerebellar Purkinje 
cell, modeled and fine-tuned by Erik de Schutter. The tutorial assumes that
you have a basic knowledge of the Purkinje cell and its synaptic inputs. It 
gives visual insight in how different properties as concentrations and 
channel conductances vary and interact within a real Purkinje cell.

In order to run the simulation, you need the following : 

1) A fast computer (Pentium200 or SPARC20) with enough memory installed (at
   least 32Mb - 64Mb, depending on which and how many programs are running)

2) Genesis 2.2 installed and correctly configured.

3) A graphical display with at least a resolution of 1024*768

4) the UNIX shell commands : sort, touch


To explore the tutorial, do the following :

1) Make room for the graphical output : move your shell window to the lower
   right hand corner of your display.

2) Change to the directory where the TUTORIAL.g script resides. If you are
   reading this file, you should be in the correct directory.  The tutorial
   will create some files in this directory, so you will need to have write
   privileges.  If the tutorial is installed in a system directory for which
   you do not have write permission, copy the tutorial files to a directory
   in which you are allowed to create files.

3) At the shell prompt, type "./TUTORIAL".  (This Unix shell script will
   create any needed files and will start GENESIS using the TUTORIAL.g
   script.  You do not need to start GENESIS yourself.)  After a long
   initialization period, a window with a Purkinje cell and a control panel
   will appear. To move on, click the 'Help' button in the control panel.
   This will popup the on-line help window.  These instructions, which you
   will need to read before running the tutorial, are contained in the file
   "help.txt".

Ambitious users can run this tutorial using different model setup files
(all the files titled Purk_*, including the morphology file, can be
changed).  Before you do so you need to reconfigure the simulation by 
running "genesis makeconfig.g". After some diagnostic messages, you 
should return to the shell prompt.

For feedback write:
Concepts and documentation: Erik de Schutter - erik@bbf.uia.ac.be
Bugs:                       Hugo Cornelis - hugo@bbf.uia.ac.be

Consult our webpages at bbf-www.uia.ac.be for relevant publications and
additional documentation concerning the model scripts.

Copyright for all the scripts: Born-Bunge Foundation - UA 1998-1999.