Cerebellar purkinje cell (De Schutter and Bower 1994)

 Download zip file 
Help downloading and running models
Accession:7176
Tutorial simulation of a cerebellar Purkinje cell. This tutorial is based upon a GENESIS simulation of a cerebellar Purkinje cell, modeled and fine-tuned by Erik de Schutter. The tutorial assumes that you have a basic knowledge of the Purkinje cell and its synaptic inputs. It gives visual insight in how different properties as concentrations and channel conductances vary and interact within a real Purkinje cell.
Reference:
1 . De Schutter E, Bower JM (1994) An active membrane model of the cerebellar Purkinje cell. I. Simulation of current clamps in slice. J Neurophysiol 71:375-400 [PubMed]
2 . De Schutter E, Bower JM (1994) An active membrane model of the cerebellar Purkinje cell II. Simulation of synaptic responses. J Neurophysiol 71:401-19 [PubMed]
3 . Staub C, De Schutter E, Knöpfel T (1994) Voltage-imaging and simulation of effects of voltage- and agonist-activated conductances on soma-dendritic voltage coupling in cerebellar Purkinje cells. J Comput Neurosci 1:301-11 [PubMed]
4 . De Schutter E, Bower JM (1994) Simulated responses of cerebellar Purkinje cells are independent of the dendritic location of granule cell synaptic inputs. Proc Natl Acad Sci U S A 91:4736-40 [PubMed]
5 . De Schutter E (1998) Dendritic voltage and calcium-gated channels amplify the variability of postsynaptic responses in a Purkinje cell model. J Neurophysiol 80:504-19 [PubMed]
6 . Jaeger D, De Schutter E, Bower JM (1997) The role of synaptic and voltage-gated currents in the control of Purkinje cell spiking: a modeling study. J Neurosci 17:91-106 [PubMed]
7 . de Schutter E (1994) Modelling the cerebellar Purkinje cell: experiments in computo. Prog Brain Res 102:427-41 [PubMed]
8 . De Schutter E (1997) A new functional role for cerebellar long-term depression. Prog Brain Res 114:529-42 [PubMed]
9 . Steuber V, Mittmann W, Hoebeek FE, Silver RA, De Zeeuw CI, Häusser M, De Schutter E (2007) Cerebellar LTD and pattern recognition by Purkinje cells. Neuron 54:121-36 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Cerebellum Purkinje GABA cell;
Channel(s): I Na,p; I Na,t; I T low threshold; I p,q; I A; I K; I M; I K,Ca; I Sodium; I Calcium; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Activity Patterns; Dendritic Action Potentials; Active Dendrites; Detailed Neuronal Models; Tutorial/Teaching; Synaptic Integration;
Implementer(s): Cornelis, Hugo [hugo at bbf.uia.ac.be]; Airong, Dong [tard at fimmu.com];
Search NeuronDB for information about:  Cerebellum Purkinje GABA cell; I Na,p; I Na,t; I T low threshold; I p,q; I A; I K; I M; I K,Ca; I Sodium; I Calcium; I Potassium;
//genesis
//
// $Id: info.g 1.4.2.1.2.1.1.2 Thu, 04 Apr 2002 12:46:38 +0200 hugo $
//

//////////////////////////////////////////////////////////////////////////////
//'
//' Purkinje tutorial
//'
//' (C) 1998-2002 BBF-UIA
//'
//' see our site at http://www.bbf.uia.ac.be/ for more information regarding
//' the Purkinje cell and genesis simulation software.
//'
//'
//' functional ideas ... Erik De Schutter, erik@bbf.uia.ac.be
//' genesis coding ..... Hugo Cornelis, hugo@bbf.uia.ac.be
//'
//' general feedback ... Reinoud Maex, Erik De Schutter
//'
//////////////////////////////////////////////////////////////////////////////


// info.g : help/credits functionality

int include_info

if ( {include_info} == 0 )

	include_info = 1


///
/// SH:	InfoHelp
///
/// DE:	Show help
///

function InfoHelp

	//- show the help form

	xshow /info/help
end


///
/// SH:	InfoHelpCreate
///
/// PA:	parent:	parent to create help form in (ending in '/')
///
/// DE:	Create help widgets
///

function InfoHelpCreate(parent)

str parent

	//- create a form for help

	create xform {parent}help \
		-xgeom 200 \
		-ygeom 0 \
		-wgeom 600 \
		-hgeom 800

	//- make created form current element

	pushe {parent}help

	//- create title label

	create xlabel heading \
		-label "Purkinje tutorial help"

	//- create a button for closing the window

	create xbutton close \
		-ygeom 0:parent.bottom \
		-title "Close" \
		-script "xhide "{parent}"help"

	//- create text widget for help

	create xtext help \
		-ygeom 0:heading.bottom \
		-hgeom 0:close.top \
		-filename "help.txt"

	//- go to previous current element

	pope
end


///
/// SH:	InfoCredits
///
/// DE:	Show the credits
///

function InfoCredits

	//- show the credits form

	xshow /info/credits
end


///
/// SH:	InfoCreditsCreate
///
/// PA:	parent:	parent to create credits form in (ending in '/')
///
/// DE:	Create credits widgets
///

function InfoCreditsCreate(parent)

str parent

	//- create a form for the credits

	create xform {parent}credits \
		-xgeom 200 \
		-ygeom 330 \
		-wgeom 450 \
		-hgeom 230

	//- make created form current element

	pushe {parent}credits

	//- create title label

	create xlabel heading \
		-label "Genesis script credits"

	//- create a button for closing the window

	create xbutton close \
		-ygeom 0:parent.bottom \
		-title "Close" \
		-script "xhide "{parent}"credits"

	//- create text widget for credits

	create xtext credits \
		-ygeom 0:heading.bottom \
		-hgeom 0:close.top \
		-filename "credits.txt"

	//- go to previous current element

	pope
end


///
/// SH:	InfoCreate
///
/// DE:	Create help and credits widgets
///

function InfoCreate

	//- create parent element for all information

	create neutral /info

	//- create widgets for help

	InfoHelpCreate /info/

	//- create widgets for credits

	InfoCreditsCreate /info/
end


end