Temporal decorrelation by intrinsic cellular dynamics (Wang et al 2003)

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Accession:84593
"... Recent investigations in primary visual (V1) cortical neurons have demonstrated that adaptation to prolonged changes in stimulus contrast is mediated in part through intrinsic ionic currents, a Ca2+ activated K+ current (IKCa) and especially a Na+ activated K+ current (IKNa). The present study was designed to test the hypothesis that the activation of adaptation ionic currents may provide a cellular mechanism for temporal decorrelation in V1. A conductance-based neuron model was simulated, which included an IKCa and an IKNa. We show that the model neuron reproduces the adaptive behavior of V1 neurons in response to high contrast inputs. ...". See paper for details and more.
Reference:
1 . Wang XJ, Liu Y, Sanchez-Vives MV, McCormick DA (2003) Adaptation and temporal decorrelation by single neurons in the primary visual cortex. J Neurophysiol 89:3279-93 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neocortex L2/3 pyramidal GLU cell;
Channel(s): I Na,t; I L high threshold; I K; I Calcium; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: C or C++ program;
Model Concept(s): Ion Channel Kinetics; Temporal Pattern Generation; Oscillations; Calcium dynamics; Vision;
Implementer(s): Wang, Xiao-Jing [xjwang at yale.edu];
Search NeuronDB for information about:  Neocortex L2/3 pyramidal GLU cell; I Na,t; I L high threshold; I K; I Calcium; I Potassium;
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decorr-model
images
readme.html
driver.c
header.h
myutils.c
nrutil.c
nrutil.h
rk4.c
                            
#define Cm 1.0  /*uF/cm**2 */
#define g_L 0.1
#define gc 2.0  /*mS/cm**2 */
#define p 0.5   /* soma area/total area */
#define phi 4.0  /* temperature dependence variable */
#define g_Na 45.0
#define g_K 18.0
#define g_Ca_soma 0.0                /* 0.0 */
#define g_AHP_soma 0.0               /* 0.0 */
#define g_AHP_KNa 8.0                /* 5.0 */
#define phi_factor 1.0
#define g_Ca_den 1.0
#define g_AHP_den 5.0
#define KD 30.0      /* uM */
#define influx_Ca_soma 0.002/3.0
#define influx_Na_soma 0.0003
#define A 0.173
#define R_pump 18.0*0.0002         /* 0.0002 */
#define Na_eq 8.0
#define Kp 15.0                   /*15.0 */
#define G_K_Na 0.05             /* 0.02  */
#define m_inf_max 0.37
#define EC_50 38.7
#define Hill_order 3.5
#define influx_Ca_den 0.002
#define tau_Ca_soma 240.0          /* 240.0 msec */
#define tau_Ca_den 80.0
#define V_Na 55.0
#define V_K -80.0
#define V_Ca 120.0
#define V_soma -64.8
#define V_den -64.8
#define dt 0.02f                /* integration step  msec */
#define RUNTIME 70000.0
#define selectprint 20
#define I_base 2.0
#define hi_fluc_scale 3.0
#define low_fluc_scale 0.3
#define pi 3.14159265358979