Synaptic integration of an identified nonspiking interneuron in crayfish (Takashima et al 2006)

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Accession:84599
This GENESIS simulation shows how a single or compound excitatory synaptic potential evoked by mechanosensory stimulation spreads over the dendrites of the LDS interneuron that is one of the identified nonspiking interneurons in the central nervous system of crayfish Procambarus clarkii. The model is based on physiological experiments carried out by Akira Takashima using single-electrode voltage clamp techniques and also 3-D morphometry of the interneuron carried out by Ryou Hikosaka using confocal laser scanning microscopic techniques. The physiological and morphological studies were coordinated by Masakazu Takahata.
Reference:
1 . Takashima A, Hikosaka R, Takahata M (2006) Functional significance of passive and active dendritic properties in the synaptic integration by an identified nonspiking interneuron of crayfish. J Neurophysiol 96:3157-69 [PubMed]
2 . Takahata M, Takashima A, Hikosaka R (2000) Information processing by nonspiking interneurons: passive and active properties of dendritic membrane determine synaptic integration. Biosystems 58:143-9 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Crayfish identified nonspiking interneuron;
Channel(s): I A; I K; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Influence of Dendritic Geometry; Invertebrate; Synaptic Integration;
Implementer(s): Takahata, Masakazu [takahata at sci.hokudai.ac.jp];
Search NeuronDB for information about:  I A; I K; I Potassium;
//genesis 2.1 - LDS_tab_chan.g
// This file was developed by
//       Akira Takashima.
//       Department of Biological Sciences
//       Faculry of Science
//       Hokkaido University
//       Sapporo Japan
//
//       Last update on 22 Jan. 2007 

/* FILE INFORMATION
** tabchannel implementation of LDS cell dendrititic voltage-dependent
** channels, according to :
** A.Takashima and M.Takahata(2000), 
**
** This file depends on functions and constants defined in library.g
*/

// CONSTANTS
float EREST_ACT = -60 /* LDS cell resting potl in mV */
float EK = -70
float Eex = 0.0
float Einh = -70
float SOMA_A = 1e-4		/* Square centimeters */
float Ek                         // milliVolts
float tau1 = 1.0 
float tau2 = 1.0                // msec
float gmax = 3.0e-6                      // milliSimens (1/kiloohms)

int EXPONENTIAL =   1
int SIGMOID     =   2
int LINOID      =   3


//========================================================================
//                       Delayed-rectifier K CHANNEL 
//========================================================================

function make_K_tab_chan
	if ({exists K_tab_chan})
		returnZpower               = 0

	end
	
	create		tabchannel	K_tab_chan

    	setfield K_tab_chan \
		Ek 		{EK} \				// mV
		Gbar		{360.0*SOMA_A} \		// mS
		Xpower		4 \
		Ypower		0 
               
                                                                  
                setupalpha K_tab_chan X 0.46 0 1 28 -11  \
                    0.003 0 0 0 15 -range -100 50 

		         		
end

//========================================================================


//========================================================================
//                       transient outward CHANNEL 
//========================================================================


function make_Kfast_tab_chan
	if ({exists Kfast_tab_chan})
		return
	end
	
	create		tabchannel	Kfast_tab_chan
    	setfield Kfast_tab_chan \
		Ek 		{EK} \				// mV
		Gbar		{360.0*SOMA_A} \		// mS
		Xpower		4 \
		Ypower		1 
                 

        setupalpha Kfast_tab_chan X 2.438 0 1 33 -6 \
            0.062 0 0 0 21  -range -100 50
         
        setupalpha Kfast_tab_chan Y 0.121 0 0 0 19 \
            2.6 0 1 0 -12 -range -100 50
 
end

//========================================================================


//========================================================================
//                       D-current like outward CHANNEL 
//========================================================================


function make_D_tab_chan
	if ({exists D_tab_chan})
		return
	end
	
	create		tabchannel	D_tab_chan
    	setfield D_tab_chan \
		Ek 		{EK} \				// mV
		Gbar		{360.0*SOMA_A} \		// mS
		Xpower		1  \
		Ypower		1  
                 
 
        setupalpha D_tab_chan X 0.49 0 1 31 -5 \
            0.02 0 0 0 41  -range -100 50 

        setupalpha D_tab_chan Y 0.00003 0 0 0 10 \
            0.011 0 1 17 -11  -range -100 50
		 
end

//========================================================================




//========================================================================
//                      Excitatory  Synaptic Channel 
//========================================================================

function make_Ex_chan
    if ({exists Ex_chan})
		return
    end

    create     synchan               Ex_chan
    setfield  Ex_chan  \
              Ek              {Eex}   \
              tau1            {tau1} \
              tau2            {tau2} \
              gmax            {gmax}
end


//========================================================================



//========================================================================
//                      Inhibitory  Synaptic Channel 
//========================================================================

function make_Inh_chan
    if ({exists Inh_chan})
		return
    end

    create     synchan               Inh_chan
    setfield  Inh_chan  \
              Ek              {Einh}   \
              tau1            {tau1} \
              tau2            {tau2} \
              gmax            {gmax}
end


//========================================================================


//EOF