Synaptic integration of an identified nonspiking interneuron in crayfish (Takashima et al 2006)

 Download zip file 
Help downloading and running models
Accession:84599
This GENESIS simulation shows how a single or compound excitatory synaptic potential evoked by mechanosensory stimulation spreads over the dendrites of the LDS interneuron that is one of the identified nonspiking interneurons in the central nervous system of crayfish Procambarus clarkii. The model is based on physiological experiments carried out by Akira Takashima using single-electrode voltage clamp techniques and also 3-D morphometry of the interneuron carried out by Ryou Hikosaka using confocal laser scanning microscopic techniques. The physiological and morphological studies were coordinated by Masakazu Takahata.
Reference:
1 . Takashima A, Hikosaka R, Takahata M (2006) Functional significance of passive and active dendritic properties in the synaptic integration by an identified nonspiking interneuron of crayfish. J Neurophysiol 96:3157-69 [PubMed]
2 . Takahata M, Takashima A, Hikosaka R (2000) Information processing by nonspiking interneurons: passive and active properties of dendritic membrane determine synaptic integration. Biosystems 58:143-9 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Crayfish identified nonspiking interneuron;
Channel(s): I A; I K; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Influence of Dendritic Geometry; Invertebrate; Synaptic Integration;
Implementer(s): Takahata, Masakazu [takahata at sci.hokudai.ac.jp];
Search NeuronDB for information about:  I A; I K; I Potassium;
//genesis - compartment.g
//                                                                   
//   This file was developed by De Schutter and Beeman
//   and modified by     
//       Akira Takashima.
//       Department of Biological Sciences
//       Faculry of Science
//       Hokkaido University
//       Sapporo Japan
//
//       Last update on 22 Jan. 2007


/* FUNCTIONS TO MAKE DEFAULT LIBRARY COMPARTMENTS */



function make_cylind_compartment
        // These default compartment parameters can be overridden by readcell
	float RM = 3.3333      // specific membrane resistance  (kiloohms cm^2)
	float CM = 1.0     // specific membrane capacitance (microfarads/cm^2)
	float RA = 0.03          // specific axial resistance (ohms m)
	float EREST_ACT = -70 // resting membrane potential (volts)
	float	len = 100.0e-4  // centimeter
	float	dia = 2.0e-4    // centimeter
	float PI = 3.14159
	float surface = len * dia * PI

	if (!{exists compartment})
		create	compartment compartment
	end
	setfield compartment \
		Cm		{CM * surface} \		// microF
		Ra		{4.0*RA*len / (dia*dia*PI)} \	// kiloohm
		Em  	{EREST_ACT} \			// milliV
		Rm		{RM / surface} \ 		// kiloohm
                dia             {dia} \
		len		{len} \	
		inject		0.0
end

function make_cylind_symcompartment
        // These default compartment parameters can be overridden by readcell
	float RM = 3.3333      // specific membrane resistance (kiloohms cm^2)
	float CM = 1.0      // specific membrane capacitance (microfarads/cm^2)
	float RA = 0.03        // specific axial resistance (kiloohms cm)
	float EREST_ACT = -70 // resting membrane potential (millivolts)
	float	len = 100.0e-4  // centimeter
	float	dia = 2.0e-4    // centimeter
	float PI = 3.14159
	float surface = len * dia * PI

	if (!{exists symcompartment})
		create	symcompartment symcompartment
	end
	setfield symcompartment \
		Cm		{CM * surface} \		// microF
		Ra		{4.0*RA*len / (dia*dia*PI)} \	// kiloohm
		Em  	{EREST_ACT} \			// milliV
		Rm		{RM / surface} \ 		// kiloohm
                dia             {dia} \
		len		{len} \	
		inject		0.0

end

//
/* These functions are included for compatibility with older neurokit
   versions, one does not need to call them anymore though! */

function make_sphere_compartment
        // These default compartment parameters can be overridden by readcell
	float RM = 3.3333     // specific membrane resistance (kiloohms cm^2)
	float CM = 1.0     // specific membrane capacitance (microfarads/cm^2)
	float RA = 0.03          // specific axial resistance (ohms m)
	float EREST_ACT = -70 // resting membrane potential (volts)
	float	dia = 20.0e-4
	float PI = 3.14159
	float surface = dia * dia * PI

	if (!{exists compartment_sphere})
		create	compartment compartment_sphere
	end
	setfield compartment_sphere \
		Cm		{CM * surface} \	// microF
		Ra		{8.0*RA / (dia*PI)} \	// kiloohm
		Em  	        {EREST_ACT} \			// milliV
		Rm		{RM / surface} \ 		// kiloohm
                dia             {dia} \
		len		0.0 \	
		inject		0.0
end

function make_sphere_symcompartment
        // These default compartment parameters can be overridden by readcell
	float RM = 3.3333      // specific membrane resistance (ohms m^2)
	float CM = 1.0     // specific membrane capacitance (microfarads/cm^2)
	float RA = 0.03          // specific axial resistance (ohms m)
	float EREST_ACT = -0.07 // resting membrane potential (volts)
	float	dia = 20.0e-4
	float PI = 3.14159
	float surface = dia * dia * PI

	if (!{exists symcompartment_sphere})
		create	symcompartment symcompartment_sphere
	end
	setfield symcompartment_sphere \
		Cm		{CM * surface} \		// microF
		Ra		{8.0*RA / (dia*PI)} \	// kiloohm
		Em  	        {EREST_ACT} \			// milliV
		Rm		{RM / surface} \ 		// kiloohm
                dia             {dia} \
		len		0.0   \	
		inject		0.0
end