Synaptic integration of an identified nonspiking interneuron in crayfish (Takashima et al 2006)

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Accession:84599
This GENESIS simulation shows how a single or compound excitatory synaptic potential evoked by mechanosensory stimulation spreads over the dendrites of the LDS interneuron that is one of the identified nonspiking interneurons in the central nervous system of crayfish Procambarus clarkii. The model is based on physiological experiments carried out by Akira Takashima using single-electrode voltage clamp techniques and also 3-D morphometry of the interneuron carried out by Ryou Hikosaka using confocal laser scanning microscopic techniques. The physiological and morphological studies were coordinated by Masakazu Takahata.
Reference:
1 . Takashima A, Hikosaka R, Takahata M (2006) Functional significance of passive and active dendritic properties in the synaptic integration by an identified nonspiking interneuron of crayfish. J Neurophysiol 96:3157-69 [PubMed]
2 . Takahata M, Takashima A, Hikosaka R (2000) Information processing by nonspiking interneurons: passive and active properties of dendritic membrane determine synaptic integration. Biosystems 58:143-9 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Crayfish identified nonspiking interneuron;
Channel(s): I A; I K; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Influence of Dendritic Geometry; Invertebrate; Synaptic Integration;
Implementer(s): Takahata, Masakazu [takahata at sci.hokudai.ac.jp];
Search NeuronDB for information about:  I A; I K; I Potassium;
// genesis - control.g -  Functions to make control panel for LDS cell
// This file was developed by
//       Akira Takashima.
//       Department of Biological Sciences
//       Faculry of Science
//       Hokkaido University
//       Sapporo Japan
//
//       Last update on 22 Jan. 2007
 
float tmax = 100        // msec
float dt = 0.01        // msec 
float injwidth  =  160  // msec
float injdelay  =   20.0
float injcurrent       = -1.0e-3  // microA (-1.0 nA)
float RM = 33.0   // kiloOhm*cm¡°2
float CM = 1.0    // microFarad/cm¡°2
float RA = 0.06   // kiloOhm*cm

include xtools.g
include outputs.g
include popup.g
include inputs.g

    // =================================================
    //                MAIN CONTROL PANEL
    // =================================================

function make_control_menu 
    create xform /output/control [10, 0, 250, 200] -nplabel
    pushe /output/control
    create xlabel label -hgeom 30 -bg cyan -label "MAIN CONTROL PANEL"
    create xbutton RESET -ygeom 0:label -wgeom 33%    -script reset
    create xbutton STOP  -xgeom 0:RESET -ygeom 0:label -wgeom 33% \
         -script stop   
    create xbutton QUIT -xgeom 0:STOP -ygeom 0:label -wgeom 34%\ 
        -script "xshow /output/quit_menu"
    create xdialog step -title "STEP (msec)" -script  \
        "stepbutton <widget>" -value {tmax}
    create xdialog stepsize -title "dt (msec)" -script "clockbutton <widget>"         -value {dt} 
    create xbutton synapse  -title "Change Synaptic Inputs" -script \ 
        "xshow /output/synapse_menu" 
    pope
end




// =======================================================
//  The two main functions, loadgraphs and load_menus
//  set up the forms used for graphs and control buttons
// =======================================================



function load_menus
    make_control_menu
    make_quit_menu
    make_synapse_menu
    xshow /output/control
end

//EOF