Amyloid beta (IA block) effects on a model CA1 pyramidal cell (Morse et al. 2010)

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Accession:87284
The model simulations provide evidence oblique dendrites in CA1 pyramidal neurons are susceptible to hyper-excitability by amyloid beta block of the transient K+ channel, IA. See paper for details.
Reference:
1 . Morse TM, Carnevale NT, Mutalik PG, Migliore M, Shepherd GM (2010) Abnormal Excitability of Oblique Dendrites Implicated in Early Alzheimer's: A Computational Study. Front Neural Circuits [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal cell;
Channel(s): I Na,t; I L high threshold; I N; I T low threshold; I A; I K; I h; I K,Ca;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Dendritic Action Potentials; Active Dendrites; Detailed Neuronal Models; Pathophysiology; Aging/Alzheimer`s;
Implementer(s): Carnevale, Ted [Ted.Carnevale at Yale.edu]; Morse, Tom [Tom.Morse at Yale.edu];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell; I Na,t; I L high threshold; I N; I T low threshold; I A; I K; I h; I K,Ca;
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CA1_abeta
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readme.html
cacumm.mod
cagk.mod *
cal2.mod *
can2.mod *
cat.mod *
distr.mod *
h.mod
ipulse2.mod *
kadist.mod
kaprox.mod
kdrca1.mod
na3n.mod
naxn.mod *
zcaquant.mod
aBeta.hoc
add_ca.hoc
bAP_peak_vecs.hoc
c91662.ses
C91662_Link.txt
cond_report.hoc
control_boxes.hoc
distribute_currents.hoc
fig1.jpg
fig2.jpg
fig2A_c91662.hoc
fig3.jpg
fig3.ses
fig4.jpg
fig4.ses
fig5.jpg
fig6b.jpg
figs.hoc
find_averages.hoc
fixnseg.hoc
GaspiriniEtAl2007Fig1Stimulation.ses
generate_conc_graph.hoc
gka_averager.hoc
graph_na3_kinetics.hoc
init_and_run_and_graph.hoc
leaky_distal.hoc
maxica.hoc
maxica.ses.20100525
mosinit.hoc
na3_shifter.hoc
ntc_additions.hoc
oblique_application.hoc
oblique_scaled_ka.hoc
obliques_primary_tuft.hoc
paper_fig_buttons.hoc
sectiontest.hoc
shrink_obliques.hoc
SubBranch.hoc
trigger_and_start.hoc
wait_for_go.hoc
                            
// cond_report.hoc conductance report program
// Displays the conductance densities (and equiv resistances) when called

proc cond_report() {

  soma distance()  // reset distance measurements to 0 at soma

  access soma
  g_prox_report()

  access apic[13]
  g_dist_report() // includes proximal a-type current

  access apic[33]
  g_dist_report() // includes distal a-type current

  access apic[43]
  g_dist_report()
}

proc g_prox_report() {
  g_common_report() // common currents
  print " gka_kap = ",gka_kap(0.5)," resistance = ", 1/(gka_kap(0.5)+1e-30)
  print " driving force = ", v-ek
  print " specific current = ",gka_kap(0.5)*(v-ek)
  print "-------------------------------------------------"
}
proc g_dist_report() {
  g_common_report() // common currents
  print " gka_kad = ",gka_kad(0.5)," resistance = ", 1/(gka_kad(0.5)+1e-30)
  print " driving force = ", v-ek
  print " current = ", gka_kad(0.5)*(v-ek)
  print "-------------------------------------------------"
}

proc g_common_report() {
  print "Location ",secname()," distance = ", distance(0.5)
  print " e_pas = ", g_pas(0.5), " resistance = ", 1/g_pas(0.5)
  print " driving force = ", v(0.5)-e_pas(0.5), " (negative depolarizes cell)"
  print " specific current = ", g_pas(0.5)*(v-e_pas(0.5))
  print "H"
  print " ghd_hd = ",ghd_hd(0.5), " resistance = ",1/ghd_hd(0.5)
  print " driving force = ", v(0.5) - ehd_hd
  print " specific current = ",ghd_hd(0.5)*( v(0.5) - ehd_hd)
  print "na3"
  print " g_na3 = ", thegna_na3(0.5), " resistance = ", 1/thegna_na3(0.5)
  print " driving force = ", v-ena
  print " specific current = ",thegna_na3(0.5)*(v-ena)
  print "K currents"
  print "KDR"
  print " g_kdr = ", gkdr_kdr(0.5), " resistance = ", 1/gkdr_kdr(0.5)
  print " driving force = ",(v-ek), " (negative depolarizes cell)"
  print " specific current = ", gkdr_kdr(0.5)*(v-ek)
  print "A-type"
}