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AP shape and parameter constraints in optimization of compartment models (Weaver and Wearne 2006)
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"... We construct an objective function that includes both time-aligned action potential shape error and errors in firing rate and firing regularity. We then implement a variant of simulated annealing that introduces a recentering algorithm to handle infeasible points outside the boundary constraints. We show how our objective function captures essential features of neuronal firing patterns, and why our boundary management technique is superior to previous approaches."
Weaver CM, Wearne SL (2006) The role of action potential shape and parameter constraints in optimization of compartment models
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Neuron or other electrically excitable cell;
Weaver, Christina [christina.weaver at fandm.edu];
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