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The role of ATP-sensitive potassium channels in a hippocampal neuron (Huang et al. 2007)
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"Hyperglycemia-related neuronal excitability and epileptic seizures are not uncommon in clinical practice. However, their underlying mechanism remains elusive. ATP-sensitive K(+) (K(ATP)) channels are found in many excitable cells, including cardiac myocytes, pancreatic beta cells, and neurons. These channels provide a link between the electrical activity of cell membranes and cellular metabolism. We investigated the effects of higher extracellular glucose on hippocampal K(ATP) channel activities and neuronal excitability. The cell-attached patch-clamp configuration on cultured hippocampal cells and a novel multielectrode recording system on hippocampal slices were employed. In addition, a simulation modeling hippocampal CA3 pyramidal neurons (Pinsky-Rinzel model) was analyzed to investigate the role of K(ATP) channels in the firing of simulated action potentials. ..."
Huang CW, Huang CC, Cheng JT, Tsai JJ, Wu SN (2007) Glucose and hippocampal neuronal excitability: role of ATP-sensitive potassium channels.
J Neurosci Res
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Neuron or other electrically excitable cell;
Hippocampus CA3 pyramidal GLU cell;
ATP-senstive potassium current;
Wu, Sheng-Nan [snwu at mail.ncku.edu.tw];
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Hippocampus CA3 pyramidal GLU cell
ATP-senstive potassium current
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