Olfactory bulb network model of gamma oscillations (Bathellier et al. 2006; Lagier et al. 2007)

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This model implements a network of 100 mitral cells connected with asynchronous inhibitory "synapses" that is meant to reproduce the GABAergic transmission of ensembles of connected granule cells. For appropriate parameters of this special synapse the model generates gamma oscillations with properties very similar to what is observed in olfactory bulb slices (See Bathellier et al. 2006, Lagier et al. 2007). Mitral cells are modeled as single compartment neurons with a small number of different voltage gated channels. Parameters were tuned to reproduce the fast subthreshold oscillation of the membrane potential observed experimentally (see Desmaisons et al. 1999).
1 . Bathellier B, Lagier S, Faure P, Lledo PM (2006) Circuit properties generating gamma oscillations in a network model of the olfactory bulb. J Neurophysiol 95:2678-91 [PubMed]
2 . Lagier S, Panzanelli P, Russo RE, Nissant A, Bathellier B, Sassoè-Pognetto M, Fritschy JM, Lledo PM (2007) GABAergic inhibition at dendrodendritic synapses tunes gamma oscillations in the olfactory bulb. Proc Natl Acad Sci U S A 104:7259-64 [PubMed]
3 . Bathellier B, Lagier S, Faure P, Lledo PM (2006) Corrigendum for Bathellier et al., J Neurophysiol 95 (4) 2678-2691. J Neurophysiol 95:3961-3962
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Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Olfactory bulb;
Cell Type(s): Olfactory bulb main mitral GLU cell;
Channel(s): I Na,p; I Na,t; I A; I K;
Gap Junctions:
Receptor(s): GabaA;
Simulation Environment: C or C++ program;
Model Concept(s): Oscillations; Delay; Olfaction;
Search NeuronDB for information about:  Olfactory bulb main mitral GLU cell; GabaA; I Na,p; I Na,t; I A; I K;

	Injector.h													JJS 9/11/95
		part of CONICAL, the Computational Neuroscience Class Library
	An Injector is an ideal Current source, that is, one which provides
	a constant current regardless of the potential of the voltage sink
	to which it is attached.  Such a current source has an infinite
	internal resistance, i.e. zero conductance, and an infinite source
	potential, so that the current (E-V)G = EG-VG = EG for finite V.
	This is implemented by keeping G equal to 0, but letting EG return
	E (as if G=1) -- a bit of a double standard.  Additional methods
	SetI and GetI are implemented to allow this class to be used in
	a more technically correct manner.

		Current			-- base class

#ifndef INJECTOR_H
#define INJECTOR_H

#include "CurrentRk4.h"

class Injector : public Current

	Injector( VSink *pTo, real pI=0 )				// constructor
	: Current( pTo, 0, pI ) {}
	virtual void SetI( real pI ) { E = pI; }		// setter
	virtual real GetI( void ) const { return E; }			// inspectors
	virtual real GetEG( void ) const { return E; }
    virtual real GetEGk1(void) const { return E; }      // inspectors Runge Kutta
	virtual real GetEGk2(void) const { return E; }
	virtual real GetEGk3(void) const { return E; }