Olfactory bulb network model of gamma oscillations (Bathellier et al. 2006; Lagier et al. 2007)

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This model implements a network of 100 mitral cells connected with asynchronous inhibitory "synapses" that is meant to reproduce the GABAergic transmission of ensembles of connected granule cells. For appropriate parameters of this special synapse the model generates gamma oscillations with properties very similar to what is observed in olfactory bulb slices (See Bathellier et al. 2006, Lagier et al. 2007). Mitral cells are modeled as single compartment neurons with a small number of different voltage gated channels. Parameters were tuned to reproduce the fast subthreshold oscillation of the membrane potential observed experimentally (see Desmaisons et al. 1999).
1 . Bathellier B, Lagier S, Faure P, Lledo PM (2006) Circuit properties generating gamma oscillations in a network model of the olfactory bulb. J Neurophysiol 95:2678-91 [PubMed]
2 . Lagier S, Panzanelli P, Russo RE, Nissant A, Bathellier B, Sassoè-Pognetto M, Fritschy JM, Lledo PM (2007) GABAergic inhibition at dendrodendritic synapses tunes gamma oscillations in the olfactory bulb. Proc Natl Acad Sci U S A 104:7259-64 [PubMed]
3 . Bathellier B, Lagier S, Faure P, Lledo PM (2006) Corrigendum for Bathellier et al., J Neurophysiol 95 (4) 2678-2691. J Neurophysiol 95:3961-3962
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Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Olfactory bulb;
Cell Type(s): Olfactory bulb main mitral GLU cell;
Channel(s): I Na,p; I Na,t; I A; I K;
Gap Junctions:
Receptor(s): GabaA;
Simulation Environment: C or C++ program;
Model Concept(s): Oscillations; Delay; Olfaction;
Search NeuronDB for information about:  Olfactory bulb main mitral GLU cell; GabaA; I Na,p; I Na,t; I A; I K;

	Stepper.h													JJS 8/29/95
		part of CONICAL, the Computational Neuroscience Class Library
	A Stepper is any object which needs to be updated at each tick of the
	clock; that is, it needs to receive a regular Step(dt) call.


#ifndef STEPPER_H
#define STEPPER_H

#ifndef real
#define real double

#include "StepmstrRk4.h"

// global variable, instantiated in Stepmstr.cxx:
extern Stepmaster gStepmaster;

class Stepper
	friend class Stepmaster;

	Stepper( )								// constructor
	 : itsMaster(0)	{ gStepmaster.Attach( *this ); }

	~Stepper( )								// destructor
		{ if (itsMaster) itsMaster->Remove( *this ); }
	virtual void Step( const real dt )		// update whatever
		{  /* null method */  }
    virtual void Stepk1( const real dt )		// update whatever dedicated to step 1 of the Rk4
		{  /* null method */  }
    virtual void Stepk2( const real dt )		// update whatever dedicated to step 2
		{  /* null method */  }
    virtual void Stepk3( const real dt )		// update whatever dedicated to step 3
		{  /* null method */  }
    virtual void Stepk4( const real dt )		// update whatever dedicated to step 4
		{  /* null method */  }
    virtual void Init(const real dt){}	                // initialize

	Stepmaster *itsMaster;			// Stepmaster to which it's attached