Optimal deep brain stimulation of the subthalamic nucleus-a computational study (Feng et al. 2007)

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Accession:93449
Here, we use a biophysically-based model of spiking cells in the basal ganglia (Terman et al., Journal of Neuroscience, 22, 2963-2976, 2002; Rubin and Terman, Journal of Computational Neuroscience, 16, 211-235, 2004) to provide computational evidence that alternative temporal patterns of DBS inputs might be equally effective as the standard high-frequency waveforms, but require lower amplitudes. Within this model, DBS performance is assessed in two ways. First, we determine the extent to which DBS causes Gpi (globus pallidus pars interna) synaptic outputs, which are burstlike and synchronized in the unstimulated Parkinsonian state, to cease their pathological modulation of simulated thalamocortical cells. Second, we evaluate how DBS affects the GPi cells' auto- and cross-correlograms.
Reference:
1 . Terman D, Rubin JE, Yew AC, Wilson CJ (2002) Activity patterns in a model for the subthalamopallidal network of the basal ganglia. J Neurosci 22:2963-76 [PubMed]
2 . Rubin JE, Terman D (2004) High frequency stimulation of the subthalamic nucleus eliminates pathological thalamic rhythmicity in a computational model. J Comput Neurosci 16:211-35 [PubMed]
3 . Feng XJ, Shea-Brown E, Greenwald B, Kosut R, Rabitz H (2007) Optimal deep brain stimulation of the subthalamic nucleus--a computational study. J Comput Neurosci 23:265-82 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Basal ganglia;
Cell Type(s): Globus pallidus neuron;
Channel(s): I T low threshold; I Sodium; I Potassium;
Gap Junctions:
Receptor(s): Glutamate; Gaba;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: C or C++ program;
Model Concept(s): Parkinson's; Deep brain stimulation;
Implementer(s): Feng, Xiao-Jiang [xfeng at mahler.princeton.edu];
Search NeuronDB for information about:  Glutamate; Gaba; I T low threshold; I Sodium; I Potassium; Gaba; Glutamate; 
CC = mpiCC
LD = mpiCC
CFLAGS = -Wall -O3 -ansi 
C_OBJ_BUILD = $(CC) $(CFLAGS) -c
PROGRAM = test.exe
OBJS = control.o integrator.o convlv.o realft.o twofft.o four1.o nrutil.o

$(PROGRAM) : $(OBJS)
	$(LD) $(OBJS) /home/xfeng/lib/odepack/liblsoda.a /usr/lib/gcc-lib/i386-redhat-linux/3.3.3/libg2c.a -o $@

control.o : control.C control.h integrator.h
	$(C_OBJ_BUILD) $<
integrator.o : integrator.C control.h integrator.h 
	$(C_OBJ_BUILD) $< 
convlv.o : convlv.c nrutil.h 
	$(C_OBJ_BUILD) $<
realft.o : realft.c nrutil.h 
	$(C_OBJ_BUILD) $<
twofft.o : twofft.c nrutil.h 
	$(C_OBJ_BUILD) $<
four1.o : four1.c 
	$(C_OBJ_BUILD) $<
nrutil.o : nrutil.c nrutil.h
	$(C_OBJ_BUILD) $<
clean :
	rm *.o