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Ion channel modeling with whole cell and a genetic algorithm (Gurkiewicz and Korngreen 2007)
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"... Here we show that a genetic search algorithm in combination with a gradient descent algorithm can be used to fit whole-cell voltage-clamp data to kinetic models with a high degree of accuracy. Previously, ion channel stimulation traces were analyzed one at a time, the results of these analyses being combined to produce a picture of channel kinetics. Here the entire set of traces from all stimulation protocols are analysed simultaneously. The algorithm was initially tested on simulated current traces produced by several Hodgkin-Huxley–like and Markov chain models of voltage-gated potassium and sodium channels. ... Finally, the algorithm was used for finding the kinetic parameters of several voltage-gated sodium and potassium channels models by matching its results to data recorded from layer 5 pyramidal neurons of the rat cortex in the nucleated outside-out patch configuration. The minimization scheme gives electrophysiologists a tool for reproducing and simulating voltage-gated ion channel kinetics at the cellular level."
Gurkiewicz M, Korngreen A (2007) A numerical approach to ion channel modelling using whole-cell voltage-clamp recordings and a genetic algorithm.
PLoS Comput Biol
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NEURON (web link to model);
Ion Channel Kinetics;
Korngreen, Alon [alon.korngreen at gmail.com];
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