MicrocircuitDB: O-LM interneuron model (Lawrence et al. 2006)

O-LM interneuron model (Lawrence et al. 2006)

Download zip file Auto-launch
Help downloading and running models

Model Information
Model File
Model Views
Simulation Platform

Accession:102288

Exploring the kinetics and distribution of the muscarinic potassium channel, IM, in 2 O-LM interneuron morphologies. Modulation of the ion channel by drugs such as XE991 (antagonist) and retigabine (agonist) are simulated in the models to examine the role of IM in spiking properties.
Reference:
1 . Lawrence JJ, Saraga F, Churchill JF, Statland JM, Travis KE, Skinner FK, McBain CJ (2006) Somatodendritic Kv7/KCNQ/M channels control interspike interval in hippocampal interneurons. J Neurosci 26:12325-38 [PubMed]

Citations Citation Browser

Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):	Hippocampus CA1 interneuron oriens alveus GABA cell;
Channel(s):	I L high threshold; I N; I T low threshold; I A; I K; I K,leak; I M; I h; I K,Ca;
Gap Junctions:
Receptor(s):	Muscarinic;
Gene(s):
Transmitter(s):
Simulation Environment:	NEURON;
Model Concept(s):	Ion Channel Kinetics; Oscillations; Detailed Neuronal Models; Action Potentials;
Implementer(s):