MicrocircuitDB: CA1 pyramidal neuron: functional significance of axonal Kv7 channels (Shah et al. 2008)

CA1 pyramidal neuron: functional significance of axonal Kv7 channels (Shah et al. 2008)

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Accession:112546

The model used in this paper confirmed the experimental findings suggesting that axonal Kv7 channels are critically and uniquely required for determining the inherent spontaneous firing of hippocampal CA1 pyramids, independently of alterations in synaptic activity. The model predicts that the axonal Kv7 density could be 3-5 times that at the soma.
Reference:
1 . Shah MM, Migliore M, Valencia I, Cooper EC, Brown DA (2008) Functional significance of axonal Kv7 channels in hippocampal pyramidal neurons. Proc Natl Acad Sci U S A 105:7869-74 [PubMed]

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Model Type:	Neuron or other electrically excitable cell; Axon; Channel/Receptor;
Brain Region(s)/Organism:
Cell Type(s):	Hippocampus CA1 pyramidal GLU cell;
Channel(s):	I Na,t; I T low threshold; I A; I K; I M; I Calcium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	NEURON;
Model Concept(s):	Action Potential Initiation; Detailed Neuronal Models; Axonal Action Potentials; Action Potentials;
Implementer(s):	Migliore, Michele [Michele.Migliore at Yale.edu];