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Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
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Accession:
112834
"We describe a computational model of the principal cell in the nucleus accumbens (NAcb), the medium spiny projection (MSP) neuron. The model neuron, constructed in NEURON, includes all of the known ionic currents in these cells and receives synaptic input from simulated spike trains via NMDA, AMPA, and GABAA receptors. ... results suggest that afferent information integration by the NAcb MSP cell may be compromised by pathology in which the NMDA current is altered or modulated, as has been proposed in both schizophrenia and addiction."
Reference:
1 .
Wolf JA, Moyer JT, Lazarewicz MT, Contreras D, Benoit-Marand M, O'Donnell P, Finkel LH (2005) NMDA/AMPA ratio impacts state transitions and entrainment to oscillations in a computational model of the nucleus accumbens medium spiny projection neuron.
J Neurosci
25
:9080-95
[
PubMed
]
Citations
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Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Nucleus accumbens spiny projection neuron;
Channel(s):
I Na,p;
I Na,t;
I L high threshold;
I N;
I T low threshold;
I A;
I h;
I K,Ca;
I Krp;
I R;
I Q;
Gap Junctions:
Receptor(s):
GabaA;
AMPA;
NMDA;
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
Model Concept(s):
Oscillations;
Schizophrenia;
Addiction;
Implementer(s):
Wolf, John A. [johnwolf at warpmail.net];
Moyer, Jason [jtmoyer at seas.upenn.edu];
Search NeuronDB
for information about:
GabaA
;
AMPA
;
NMDA
;
I Na,p
;
I Na,t
;
I L high threshold
;
I N
;
I T low threshold
;
I A
;
I h
;
I K,Ca
;
I Krp
;
I R
;
I Q
;
Download the displayed file
/
nacb_msp
tau_tables
readme.html
AMPA.mod
bkkca.mod
*
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Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
cadyn.mod
*
Other models using cadyn.mod:
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
caL.mod
*
Other models using caL.mod:
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
caL13.mod
*
Other models using caL13.mod:
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
caldyn.mod
can.mod
*
Other models using can.mod:
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
caq.mod
*
Other models using caq.mod:
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
car.mod
*
Other models using car.mod:
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
cat.mod
*
Other models using cat.mod:
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
GABA.mod
*
Other models using GABA.mod:
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Effects of KIR current inactivation in NAc Medium Spiny Neurons (Steephen and Manchanda 2009)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
kaf.mod
*
Other models using kaf.mod:
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
kas.mod
*
Other models using kas.mod:
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
kir.mod
*
Other models using kir.mod:
A model of optimal learning with redundant synaptic connections (Hiratani & Fukai 2018)
Dendritic Discrimination of Temporal Input Sequences (Branco et al. 2010)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
krp.mod
*
Other models using krp.mod:
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
naf.mod
*
Other models using naf.mod:
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
nap.mod
*
Other models using nap.mod:
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
NMDA.mod
skkca.mod
*
Other models using skkca.mod:
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
stim.mod
*
Other models using stim.mod:
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
_run_me.hoc
all_tau_vecs.hoc
*
Other models using all_tau_vecs.hoc:
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
baseline_values.txt
*
Other models using baseline_values.txt:
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
basic_procs.hoc
create_mspcells.hoc
*
Other models using create_mspcells.hoc:
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
current_clamp.ses
*
Other models using current_clamp.ses:
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
make_netstims.hoc
mosinit.hoc
*
Other models using mosinit.hoc:
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
msp_template.hoc
nacb_main.hoc
netstims_template.hoc
*
Other models using netstims_template.hoc:
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
screenshot.jpg
screenshot2.jpg
stimxout_jns_sqwave.dat
synapse_templates.hoc
load_file("nrngui.hoc") load_file("_run_me.hoc")
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