MicrocircuitDB: Hodgkin-Huxley model of persistent activity in prefrontal cortex neurons (Winograd et al. 2008)

Hodgkin-Huxley model of persistent activity in prefrontal cortex neurons (Winograd et al. 2008)

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Accession:113997

The paper demonstrate a form of graded persistent activity activated by hyperpolarization. This phenomenon is modeled based on a slow calcium regulation of Ih, similar to that introduced earlier for thalamic neurons (see Destexhe et al., J Neurophysiol. 1996). The only difference is that the calcium signal is here provided by the high-threshold calcium current (instead of the low-threshold calcium current in thalamic neurons).
Reference:
1 . Winograd M, Destexhe A, Sanchez-Vives MV (2008) Hyperpolarization-activated graded persistent activity in the prefrontal cortex. Proc Natl Acad Sci U S A 105:7298-303 [PubMed]

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Model Type:	Neuron or other electrically excitable cell; Channel/Receptor;
Brain Region(s)/Organism:	Prefrontal cortex (PFC);
Cell Type(s):
Channel(s):	I Na,t; I L high threshold; I K; I M; I h;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	NEURON;
Model Concept(s):	Activity Patterns; Ion Channel Kinetics;
Implementer(s):	Destexhe, Alain [Destexhe at iaf.cnrs-gif.fr];