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Lateral dendrodenditic inhibition in the Olfactory Bulb (David et al. 2008)
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Accession:
116094
Mitral cells, the principal output neurons of the olfactory bulb, receive direct synaptic activation from primary sensory neurons. Shunting inhibitory inputs delivered by granule cell interneurons onto mitral cell lateral dendrites are believed to influence spike timing and underlie coordinated field potential oscillations. Lateral dendritic shunt conductances delayed spiking to a degree dependent on both their electrotonic distance and phase of onset. Recurrent inhibition significantly narrowed the distribution of mitral cell spike times, illustrating a tendency towards coordinated synchronous activity. This result suggests an essential role for early mechanisms of temporal coordination in olfaction. The model was adapted from Davison et al, 2003, but include additional noise mechanisms, long lateral dendrite, and specific synaptic point processes.
Reference:
1 .
David F, Linster C, Cleland TA (2008) Lateral dendritic shunt inhibition can regularize mitral cell spike patterning.
J Comput Neurosci
25
:25-38
[
PubMed
]
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Model Information
(Click on a link to find other models with that property)
Model Type:
Realistic Network;
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Olfactory bulb;
Cell Type(s):
Olfactory bulb main mitral GLU cell;
Olfactory bulb main interneuron granule MC GABA cell;
Channel(s):
I Na,t;
I L high threshold;
I A;
I K;
I K,Ca;
Gap Junctions:
Receptor(s):
GabaA;
AMPA;
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
MATLAB;
Model Concept(s):
Temporal Pattern Generation;
Synchronization;
Simplified Models;
Active Dendrites;
Olfaction;
Implementer(s):
Search NeuronDB
for information about:
Olfactory bulb main mitral GLU cell
;
Olfactory bulb main interneuron granule MC GABA cell
;
GabaA
;
AMPA
;
I Na,t
;
I L high threshold
;
I A
;
I K
;
I K,Ca
;
/
DendroDendriticInhibition
LongDendrite
cadecay.mod
*
Other models using cadecay.mod:
Lateral dendrodenditic inhibition in the Olfactory Bulb (David et al. 2008)
kA.mod
*
Other models using kA.mod:
Lateral dendrodenditic inhibition in the Olfactory Bulb (David et al. 2008)
Olfactory Bulb Network (Davison et al 2003)
Parallel network simulations with NEURON (Migliore et al 2006)
kca.mod
*
Other models using kca.mod:
Lateral dendrodenditic inhibition in the Olfactory Bulb (David et al. 2008)
Olfactory Bulb Network (Davison et al 2003)
Parallel network simulations with NEURON (Migliore et al 2006)
kfasttab.mod
*
Other models using kfasttab.mod:
2D model of olfactory bulb gamma oscillations (Li and Cleland 2017)
A two-layer biophysical olfactory bulb model of cholinergic neuromodulation (Li and Cleland 2013)
Lateral dendrodenditic inhibition in the Olfactory Bulb (David et al. 2008)
Mitral cell activity gating by respiration and inhibition in an olfactory bulb NN (Short et al 2016)
Olfactory Bulb Network (Davison et al 2003)
Parallel network simulations with NEURON (Migliore et al 2006)
kM.mod
*
Other models using kM.mod:
2D model of olfactory bulb gamma oscillations (Li and Cleland 2017)
A two-layer biophysical olfactory bulb model of cholinergic neuromodulation (Li and Cleland 2013)
Lateral dendrodenditic inhibition in the Olfactory Bulb (David et al. 2008)
Mitral cell activity gating by respiration and inhibition in an olfactory bulb NN (Short et al 2016)
Olfactory Bulb Network (Davison et al 2003)
Parallel network simulations with NEURON (Migliore et al 2006)
kslowtab.mod
*
Other models using kslowtab.mod:
2D model of olfactory bulb gamma oscillations (Li and Cleland 2017)
A two-layer biophysical olfactory bulb model of cholinergic neuromodulation (Li and Cleland 2013)
Lateral dendrodenditic inhibition in the Olfactory Bulb (David et al. 2008)
Mitral cell activity gating by respiration and inhibition in an olfactory bulb NN (Short et al 2016)
Olfactory Bulb Network (Davison et al 2003)
Parallel network simulations with NEURON (Migliore et al 2006)
lcafixed.mod
*
Other models using lcafixed.mod:
Lateral dendrodenditic inhibition in the Olfactory Bulb (David et al. 2008)
Olfactory Bulb Network (Davison et al 2003)
Parallel network simulations with NEURON (Migliore et al 2006)
nafast.mod
*
Other models using nafast.mod:
Lateral dendrodenditic inhibition in the Olfactory Bulb (David et al. 2008)
Olfactory Bulb Network (Davison et al 2003)
Parallel network simulations with NEURON (Migliore et al 2006)
nmdanet.mod
*
Other models using nmdanet.mod:
2D model of olfactory bulb gamma oscillations (Li and Cleland 2017)
A two-layer biophysical olfactory bulb model of cholinergic neuromodulation (Li and Cleland 2013)
Mitral cell activity gating by respiration and inhibition in an olfactory bulb NN (Short et al 2016)
Olfactory Bulb Network (Davison et al 2003)
Parallel network simulations with NEURON (Migliore et al 2006)
shuntInhib.mod
*
Other models using shuntInhib.mod:
Lateral dendrodenditic inhibition in the Olfactory Bulb (David et al. 2008)
stim2.mod
bulb.hoc
experiment_fig1.hoc
experiment_fig2ace.hoc
fig1bde.dat
fig1bde.m
fig1bde.ses
fig1fg.m
fig1fg.ses
fig2ace.m
fig2ace.ses
granule.tem
init.hoc
input.hoc
mathslib.hoc
*
Other models using mathslib.hoc:
Lateral dendrodenditic inhibition in the Olfactory Bulb (David et al. 2008)
Olfactory Bulb Network (Davison et al 2003)
Parallel network simulations with NEURON (Migliore et al 2006)
mitral.tem
mosinit.hoc
*
Other models using mosinit.hoc:
Biophysical and phenomenological models of spike-timing dependent plasticity (Badoual et al. 2006)
Lateral dendrodenditic inhibition in the Olfactory Bulb (David et al. 2008)
Olfactory Bulb Network (Davison et al 2003)
Parallel network simulations with NEURON (Migliore et al 2006)
parameters_fig1.hoc
parameters_fig2ace.hoc
tabchannels.dat
*
Other models using tabchannels.dat:
2D model of olfactory bulb gamma oscillations (Li and Cleland 2017)
A two-layer biophysical olfactory bulb model of cholinergic neuromodulation (Li and Cleland 2013)
Lateral dendrodenditic inhibition in the Olfactory Bulb (David et al. 2008)
Olfactory Bulb Network (Davison et al 2003)
Olfactory bulb microcircuits model with dual-layer inhibition (Gilra & Bhalla 2015)
Parallel network simulations with NEURON (Migliore et al 2006)
tabchannels.hoc
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Long Dendrite - Fig1bde
Long Dendrite - Fig1fg
Long Dendrite - Fig2ace
Short Dendrite - Fig1cde
Short Dendrite - Fig1fg
Short Dendrite - Fig2bf
Short Dendrite - Fig3
Short Dendrite - Fig4abcd
Short Dendrite - Fig4ef
Short Dendrite - Fig5
Short Dendrite - Fig6
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