Currents contributing to decision making in neurons B31-B32 of Aplysia (Hurwitz et al. 2008)

 Download zip file 
Help downloading and running models
Accession:116606
"Biophysical properties of neurons contributing to the ability of an animal to decide whether or not to respond were examined. B31/B32, two pairs of bilaterally symmetrical Aplysia neurons, are major participants in deciding to initiate a buccal motor program, the neural correlate of a consummatory feeding response. B31/B32 respond to an adequate stimulus after a delay, during which time additional stimuli influence the decision to respond. B31/B32 then respond with a ramp depolarization followed by a sustained soma depolarization and axon spiking that is the expression of a commitment to respond to food. Four currents contributing to decision making in B31/B32 were characterized, and their functional effects were determined, in current- and voltage-clamp experiments and with simulations. ... Hodgkin-Huxley kinetic analyses were performed on the outward currents. Simulations using equations from these analyses showed that IK-V and IK-A slow the ramp depolarization preceding the sustained depolarization. The three outward currents contribute to braking the B31/B32 depolarization and keeping the sustained depolarization at a constant voltage. The currents identified are sufficient to explain the properties of B31/B32 that play a role in generating the decision to feed."
Reference:
1 . Hurwitz I, Ophir A, Korngreen A, Koester J, Susswein AJ (2008) Currents contributing to decision making in neurons B31/B32 of Aplysia. J Neurophysiol 99:814-30 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Aplysia;
Cell Type(s): Aplysia B31/B32 neuron;
Channel(s): I Na,t; I A; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: SNNAP;
Model Concept(s): Action Selection/Decision Making;
Implementer(s):
Search NeuronDB for information about:  I Na,t; I A; I K;
/
hurwitzEtAl2008
with_all_currents_slow_stimulus
B_B63_K.a *
B_B63_K.b *
B_B63_Na.A *
B_B63_Na.B *
b31_axon.neu *
B31_axon_2_Soma.es *
b31_axon_K.vdg *
b31_axon_K2.vdg *
b31_axon_leak.vdg *
b31_axon_Na.vdg *
b31_leak_fixed.vdg *
b31_leak_only.neu *
b31_soma_K1.A *
b31_soma_K1.B *
b31_soma_K1.vdg *
b31_soma_K2.A *
b31_soma_K2.B *
b31_soma_K2.vdg *
b31_soma_K3.A *
b31_soma_K3.B *
b31_soma_K3.vdg *
b31_with_axon.ntw *
b31_with_axon.ous
b31_with_axon.ous.mnu
b31_with_axon.smu
b31_with_axon.smu.exec
b31_with_axon.smu.hmn
b31_with_axon.smu.ing
b31_with_axon.trt
b31_with_axon_vc.trt *
b31_with_axon_with_I_del.ous *
Copy of b31_with_axon.trt
ousgrf.def *
simufiles.usd
                            
        >>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
        >>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
        >>   modules name: trt          >>
        >>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
        >>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>


>----------------------->------------------------------->
  CURNT_INJ:            > Timing for currnt injection   >
>.......................>...............................>
        b31_leak_only   > Name of Neuron                >
>.......................>...............................>
        0.00            >       Start injection         >
>.......................>...............................>
        0.50            >       Stop injection          >
>.......................>...............................>
        0.25            >       Magnitude               >
>.......................>...............................>
        b31_leak_only   > Name of Neuron                >
>.......................>...............................>
        0.50            >       Start injection         >
>.......................>...............................>
        0.90            >       Stop injection          >
>.......................>...............................>
        0.50            >       Magnitude               >
>.......................>...............................>
        b31_leak_only   > Name of Neuron                >
>.......................>...............................>
        0.90            >       Start injection         >
>.......................>...............................>
        1.20            >       Stop injection          >
>.......................>...............................>
        0.75            >       Magnitude               >
>.......................>...............................>
        b31_leak_only   > Name of Neuron                >
>.......................>...............................>
        1.20            >       Start injection         >
>.......................>...............................>
        1.60            >       Stop injection          >
>.......................>...............................>
        1.00            >       Magnitude               >
>.......................>...............................>
        b31_leak_only   > Name of Neuron                >
>.......................>...............................>
        1.60            >       Start injection         >
>.......................>...............................>
        1.90            >       Stop injection          >
>.......................>...............................>
        1.40            >       Magnitude               >
>.......................>...............................>
        b31_leak_only   > Name of Neuron                >
>.......................>...............................>
        1.90            >       Start injection         >
>.......................>...............................>
        2.10            >       Stop injection          >
>.......................>...............................>
        1.70            >       Magnitude               >
>.......................>...............................>
        b31_leak_only   > Name of Neuron                >
>.......................>...............................>
        2.10            >       Start injection         >
>.......................>...............................>
        2.40            >       Stop injection          >
>.......................>...............................>
        2.10            >       Magnitude               >
>.......................>...............................>
        b31_leak_only   > Name of Neuron                >
>.......................>...............................>
        2.40            >       Start injection         >
>.......................>...............................>
        2.65            >       Stop injection          >
>.......................>...............................>
        2.50            >       Magnitude               >
>.......................>...............................>
        b31_leak_only   > Name of Neuron                >
>.......................>...............................>
        2.65            >       Start injection         >
>.......................>...............................>
        2.80            >       Stop injection          >
>.......................>...............................>
        3.00            >       Magnitude               >
>.......................>...............................>
        b31_leak_only   > Name of Neuron                >
>.......................>...............................>
        2.80            >       Start injection         >
>.......................>...............................>
        2.95            >       Stop injection          >
>.......................>...............................>
        3.75            >       Magnitude               >
>.......................>...............................>
        b31_leak_only   > Name of Neuron                >
>.......................>...............................>
        2.95            >       Start injection         >
>.......................>...............................>
        3.10            >       Stop injection          >
>.......................>...............................>
        4.00            >       Magnitude               >
>.......................>...............................>
        b31_leak_only   > Name of Neuron                >
>.......................>...............................>
        3.10            >       Start injection         >
>.......................>...............................>
        3.25            >       Stop injection          >
>.......................>...............................>
        4.50            >       Magnitude               >
>.......................>...............................>
        b31_leak_only   > Name of Neuron                >
>.......................>...............................>
        3.25            >       Start injection         >
>.......................>...............................>
        3.45            >       Stop injection          >
>.......................>...............................>
        5.00            >       Magnitude               >
>.......................>...............................>
        b31_leak_only   > Name of Neuron                >
>.......................>...............................>
        3.45            >       Start injection         >
>.......................>...............................>
        3.55            >       Stop injection          >
>.......................>...............................>
        5.50            >       Magnitude               >
>.......................>...............................>
        b31_leak_only   > Name of Neuron                >
>.......................>...............................>
        3.55            >       Start injection         >
>.......................>...............................>
        3.65            >       Stop injection          >
>.......................>...............................>
        6.00            >       Magnitude               >
>.......................>...............................>
        b31_leak_only   > Name of Neuron                >
>.......................>...............................>
        3.65            >       Start injection         >
>.......................>...............................>
        3.70            >       Stop injection          >
>.......................>...............................>
        7.00            >       Magnitude               >
>.......................>...............................>
        b31_leak_only   > Name of Neuron                >
>.......................>...............................>
        3.70            >       Start injection         >
>.......................>...............................>
        3.75            >       Stop injection          >
>.......................>...............................>
        8.00           >       Magnitude               >
>.......................>...............................>
        b31_leak_only   > Name of Neuron                >
>.......................>...............................>
        3.75            >       Start injection         >
>.......................>...............................>
        4.00            >       Stop injection          >
>.......................>...............................>
        9.00            >       Magnitude               >
>.......................>...............................>
        b31_leak_only   > Name of Neuron                >
>.......................>...............................>
        4.00            >       Start injection         >
>.......................>...............................>
        4.25            >       Stop injection          >
>.......................>...............................>
        10.00           >       Magnitude               >
>.......................>...............................>
        b31_leak_only   > Name of Neuron                >
>.......................>...............................>
        4.25             >       Start injection         >
>.......................>...............................>
        4.50            >       Stop injection          >
>.......................>...............................>
        12.00           >       Magnitude               >
>.......................>...............................>
        b31_leak_only   > Name of Neuron                >
>.......................>...............................>
	4.50            >       Start injection         >
>.......................>...............................>
        5.00            >       Stop injection          >
>.......................>...............................>
        15.00           >       Magnitude               >
>.......................>...............................>
       b31_leak_only    > Name of Neuron                >
>.......................>...............................>
	5.00            >       Start injection         >
>.......................>...............................>
        5.50            >       Stop injection          >
>.......................>...............................>
        18.00           >       Magnitude               >
>.......................>...............................>
       b31_leak_only    > Name of Neuron                >
>.......................>...............................>
	5.50            >       Start injection         >
>.......................>...............................>
        5.75            >       Stop injection          >
>.......................>...............................>
        21.00           >       Magnitude               >
>.......................>...............................>
       b31_leak_only    > Name of Neuron                >
>.......................>...............................>
	5.75            >       Start injection         >
>.......................>...............................>
        6.00            >       Stop injection          >
>.......................>...............................>
        24.00           >       Magnitude               >
>.......................>...............................>
       b31_leak_only    > Name of Neuron                >
>.......................>...............................>
	6.00            >       Start injection         >
>.......................>...............................>
        6.25            >       Stop injection          >
>.......................>...............................>
        27.00           >       Magnitude               >
>.......................>...............................>
      b31_leak_only     > Name of Neuron                >
>.......................>...............................>
	6.25            >       Start injection         >
>.......................>...............................>
        6.50            >       Stop injection          >
>.......................>...............................>
        30.00           >       Magnitude               >
>.......................>...............................>
       b31_leak_only    > Name of Neuron                >
>.......................>...............................>
	6.50            >       Start injection         >
>.......................>...............................>
        7.00            >       Stop injection          >
>.......................>...............................>
        32.00           >       Magnitude               >
>.......................>...............................>
       b31_leak_only    > Name of Neuron                >
>.......................>...............................>
	7.00            >       Start injection         >
>.......................>...............................>
        7.50            >       Stop injection          >
>.......................>...............................>
        35.00           >       Magnitude               >
>.......................>...............................>
      b31_leak_only    > Name of Neuron                >
>.......................>...............................>
	7.50            >       Start injection         >
>.......................>...............................>
        8.00            >       Stop injection          >
>.......................>...............................>
        38.00           >       Magnitude               >
>.......................>...............................>
       b31_leak_only    > Name of Neuron                >
>.......................>...............................>
	8.00            >       Start injection         >
>.......................>...............................>
        8.50            >       Stop injection          >
>.......................>...............................>
        41.00           >       Magnitude               >
>.......................>...............................>
       b31_leak_only    > Name of Neuron                >
>.......................>...............................>
	8.50            >       Start injection         >
>.......................>...............................>
        9.00            >       Stop injection          >
>.......................>...............................>
        43.00           >       Magnitude               >
>.......................>...............................>
       b31_leak_only    > Name of Neuron                >
>.......................>...............................>
	9.00            >       Start injection         >
>.......................>...............................>
        9.50            >       Stop injection          >
>.......................>...............................>
        43.00           >       Magnitude               >
>.......................>...............................>
       b31_leak_only    > Name of Neuron                >
>.......................>...............................>
	9.50            >       Start injection         >
>.......................>...............................>
        10.00           >       Stop injection          >
>.......................>...............................>
        43.00           >       Magnitude               >
       b31_leak_only    > Name of Neuron                >
>.......................>...............................>
	10.00            >       Start injection         >
>.......................>...............................>
        23.00           >       Stop injection          >
>.......................>...............................>
        43.00           >       Magnitude               >
>----------------------->------------------------------->
        END             >                               >
>----------------------->------------------------------->

>----------------------->------------------------------->
  MOD_INJ:              > Timing for injection of       >
>----------------------->------------------------------->
        END             >                               >
>----------------------->------------------------------->

>----------------------->------------------------------->
  VCLAMP:               > Timing for V_clamping         >
>----------------------->------------------------------->
        END             >                               >
>----------------------->------------------------------->

>----------------------->------------------------------->
  ICLAMP:               > Timing for I_clamping         >
>----------------------->------------------------------->
        END             >                               >
>----------------------->------------------------------->

>----------------------->------------------------------->
  LIGHT_STIM:            > Timing for light stimulus   >
>----------------------->------------------------------->
        END             >                               >
>----------------------->------------------------------->
END