A model of the femur-tibia control system in stick insects (Stein et al. 2008)

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Accession:118092
We studied the femur-tibia joint control system of the insect leg, and its switch between resistance reflex in posture control and "active reaction" in walking. The "active reaction" is basically a reversal of the resistance reflex. Both responses are elicited by the same sensory input and the same neuronal network (the femur-tibia network). The femur-tibia network was modeled by fitting the responses of model neurons to those obtained in animals. Each implemented neuron has a physiological counterpart. The strengths of 16 interneuronal pathways that integrate sensory input were then assigned three different values and varied independently, generating a database of more than 43 million network variants. The uploaded version contains the model that best represented the resistance reflex. Please see the README for more help. We demonstrate that the combinatorial code of interneuronal pathways determines motor output. A switch between different behaviors such as standing to walking can thus be achieved by altering the strengths of selected sensory integration pathways.
Reference:
1 . Stein W, Straub O, Ausborn J, Mader W, Wolf H (2008) Motor pattern selection by combinatorial code of interneuronal pathways. J Comput Neurosci 25:543-61 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell; Synapse;
Brain Region(s)/Organism:
Cell Type(s): Stick insect nonspiking interneuron;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: MadSim;
Model Concept(s): Detailed Neuronal Models; Invertebrate; Synaptic Integration;
Implementer(s): Mader, Wolfgang [wolfgang.mader at uni-ulm.de];
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madSim4.5
parameter
Rueckkopplungs-Objekte-Dateien
! bloss oinr.knl *
1 kanal.knl *
akt+inakt.knl
dialog texte de.txt
dialog texte en.txt
dialog texte en_alt.txt
Diffgleichungen_in_madSim.pdf
GB.channel *
GB.channel.description *
GB.channel.description.doc *
gb-parameter.txt *
gb-parameter.xls *
HH.channel *
HH.channel.description *
HH.channel.description.doc *
ioTabelle langsam.txt *
ioTabelle normal.txt *
ioTabelle test.txt
ioTabelle.txt *
izhikevich-typen.txt *
izhikevich-typen.txt.orig *
meldung texte de.txt
meldung texte en.txt
neuronParameter.xls
ONOFF.channel *
ONOFF.channel.description *
ONOFF.channel.description.doc *
ONOFF.NEU *
reizFuerServerBetrieb kurz.txt *
reizFuerServerBetrieb original.txt *
reizFuerServerBetrieb.txt *
Rueckkopplungs-Objekte.htm
STANDARD.CA *
STANDARD.GEN *
STANDARD.K *
STANDARD.NA *
STANDARD.NEU *
STANDARD.ON *
standardap 2000ms.TXT *
standardap 200ms.txt *
standardap original.TXT *
standardap.txt *
swim example.txt *
SWIM.channel *
SWIM.channel.description *
SWIM.channel.description.doc *
tooltip texte de.txt
tooltip texte en.txt
userDef SWIM kanal original.txt *
userDef SWIM kanal.knl
                            
GB_CA_INITIAL	- initial calcium concentration
GB_K_ICA	- cell volume dependend, formula: (1/(2*Faraday-constant*cell_volume))
GB_K_CA	- speed of calcium restitution
GB_C0_CA	- constant background concentration of calcium
GB_CA_CA	- extracellular calcium concentration
GB_TEMP	- absolute temperature
GB_M_POWER	- power of gate variable m
GB_M_INITIAL	- initial value of gate variable m
GB_H_POWER	- power of gate variable h
GB_H_INITIAL	- initial value of gate variable h
GB_NA_G	- conductance of sodium channel
GB_NA_E	- equilibrium potential of sodium channel
GB_Form_Alpha_M	- form parameter for gate variable m, alpha term
GB_AalphaM	- rate constant
GB_V0alphaM	- half maximum potential
GB_BalphaM	- step width
GB_Form_Beta_M	- form parameter for gate variable m, beta term
GB_AbetaM	- rate constant
GB_V0betaM	- half maximum potential
GB_BbetaM	- step width
GB_Form_Alpha_H	- form parameter for gate variable h, alpha term
GB_AalphaH	- rate constant
GB_V0alphaH	- half maximum potential
GB_BalphaH	- step width
GB_Form_Beta_H	- form parameter for gate variable h, beta term
GB_AbetaH	- rate constant
GB_V0betaH	- half maximum potential
GB_BbetaH	- step width
GB_N_POWER	- power of gate variable n
GB_N_INITIAL	- initial value of gate variable n
GB_K_G	- conductance of potassium channel
GB_K_E	- equilibrium potential of potassium channel
GB_Form_Alpha_N	- form parameter for gate variable n, alpha term
GB_AinfinityN	- rate constant
GB_V0infinityN	- half maximum potential
GB_BinfinityN	- step width
GB_Form_Beta_N	- form parameter for gate variable n, beta term
GB_AtauN	- rate constant
GB_V0tauN	- half maximum potential
GB_BtauN	- step width
GB_A_POWER	- power of gate variable a
GB_A_INITIAL	- initial value of gate variable a
GB_B1_POWER	- power of gate variable beta 1
GB_B1_INITIAL	- initial value of gate variable beta 1
GB_B2_POWER	- power of gate variable beta 2
GB_B2_INITIAL	- initial value of gate variable beta 2
GB_G_POWER	- power of gate variable gamma
GB_G_INITIAL	- initial value of gate variable gamma
GB_A_G	- conductance of A-channel
GB_A_E	- equilibrium potential of A-channel
GB_Form_Alpha_A	- form parameter for gate variable a, alpha term
GB_V0a 	- half maximum potential
GB_Ba	- step width
GB_Form_Beta_A	- form parameter for gate variable a, beta term
GB_Ta 	- time constant (= 1 / rate constant)
GB_Form_Alpha_B1	- form parameter for gate variable b1, alpha term
GB_V0b1	- half maximum potential
GB_Bb1	- step width
GB_Form_Beta_B1	- form parameter for gate variable b1, beta term
GB_Tb1	- time constant (= 1 / rate constant)
GB_Form_Alpha_B2	- form parameter for gate variable b2, alpha term
GB_V0alphab2	- half maximum potential
GB_Balphab2	- step width
GB_Form_Beta_B2	- form parameter for gate variable b2, beta term
GB_Ab2	- rate constant for gate variable b2
GB_V0b2	- half maximum potential
GB_Bb2	- step width
GB_V0g	- half maximum potential for gate variable gamma
GB_Bg	- step width for gate variable gamma
GB_C_POWER	- power of gate variable c
GB_C_INITIAL	- initial value of gate variable c
GB_D_POWER	- power of gate variable d
GB_D_INITIAL	- initial value of gate variable d
GB_CA1_G	- conductance of first calcium channel
GB_Form_Alpha_C	- form parameter for gate variable c, alpha term
GB_V0c	- half maximum potential
GB_Bc	- step width
GB_Form_Beta_C	- form parameter for gate variable c, beta term
GB_Tc	- time constant (= 1 / rate constant)
GB_Form_Alpha_D	- form parameter for gate variable d, alpha term
GB_V0d	- half maximum potential
GB_Bd	- step width
GB_Form_Beta_D	- form parameter for gate variable d, beta term
GB_Td	- time constant (= 1 / rate constant)
GB_E_POWER	- power of gate variable e
GB_E_INITIAL	- initial value of gate variable e
GB_CA2_G	- conductance of second calcium channel
GB_Form_Alpha_E	- form parameter for gate variable e, alpha term
GB_V0e	- half maximum potential
GB_Be	- step width
GB_Form_Beta_E	- form parameter for gate variable e, beta term
GB_Te	- time constant (= 1 / rate constant)
GB_P_POWER	- power of gate variable p
GB_P_INITIAL	- initial value of gate variable p
GB_Q_POWER	- power of gate variable q
GB_Q_INITIAL	- initial value of gate variable q
GB_KCA_G	- conductance of calcium dependend potassium channel
GB_KCA_E	- equilibrium potential of calcium dependend potassium channel
GB_Form_Alpha_P	- form parameter for gate variable p, alpha term
GB_V0p1	- half maximum potential
GB_Bp1	- step width
GB_Form_Beta_P	- form parameter for gate variable p, beta term
GB_V0p2	- half maximum potential
GB_Bp2	- step width
GB_Tp	- time constant (= 1 / rate constant)
GB_Cca	- speed of calcium restitution for gate variable p
GB_C1	- calcium concentration constant for gate variable p
GB_Form_Alpha_Q	- form parameter for gate variable q, alpha term
GB_C2	- calcium concentration constant for gate variable q
GB_C3	- calcium concentration constant for gate variable q
GB_Form_Beta_Q	- form parameter for gate variable q, beta term
GB_Tq	- time constant (= 1 / rate constant)
GB_R_POWER	- power of gate variable r
GB_R_INITIAL	- initial value of gate variable r
GB_IR_G	- conductance of IR-channel
GB_IR_E	- equilibrium potential of IR-channel
GB_Form_Alpha_R	- form parameter for gate variable r, alpha term
GB_V0r	- half maximum potential
GB_Br	- step width
GB_Form_Beta_R	- form parameter for gate variable r, beta term
GB_Atau_r	- time constant (= 1 / rate constant)
GB_V0tau_r	- half maximum potential
GB_Btau_r	- step width
GB_S_POWER	- power of gate variable n
GB_S_INITIAL	- initial value of gate variable n
GB_P_G	- conductance of potassium channel
GB_P_E	- equilibrium potential of potassium channel
GB_Form_Alpha_S	- form parameter for gate variable s, alpha term
GB_V0s	- half maximum potential
GB_Bs	- step width
GB_Form_Beta_S	- form parameter for gate variable s, beta term
GB_Ts	- time constant (= 1 / rate constant)
GB_SPIKE_THRESHOLD	- spike threshold, used only for spike identification