Gap junction coupled network of striatal fast spiking interneurons (Hjorth et al. 2009)

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Accession:118389
Gap junctions between striatal FS neurons has very weak ability to synchronise spiking. Input uncorrelated between neighbouring neurons is shunted, while correlated input is not.
Reference:
1 . Hjorth J, Blackwell KT, Kotaleski JH (2009) Gap junctions between striatal fast-spiking interneurons regulate spiking activity and synchronization as a function of cortical activity. J Neurosci 29:5276-86 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell; Synapse; Channel/Receptor; Dendrite;
Brain Region(s)/Organism: Basal ganglia;
Cell Type(s): Neostriatum fast spiking interneuron;
Channel(s): I A; I_K,Na;
Gap Junctions: Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: GENESIS; MATLAB;
Model Concept(s): Activity Patterns; Ion Channel Kinetics; Synchronization; Detailed Neuronal Models;
Implementer(s): Hjorth, Johannes [hjorth at csc.kth.se];
Search NeuronDB for information about:  I A; I_K,Na; Gaba; Glutamate; 
These simulations take quite some time to finish, if you just want to
see the script running then lower the nReps and maxTime. Ofcourse,
this will remove all traces of significance from the results.

Have fun!

/Johannes



Figure 7A

In directory FIG7AB/ run the following matlab scripts

runTenInhomoFSwithShiftingCorr.m
readTenInhomoFSshiftCorr.m
makeShiftCorrPlotTEST.m

Note: You can use readTenInhomoFSshiftCorrTHROWAWAYDATA.m to read in
the data, this will throw away voltage data instead of storing them in
memory. If you have done alot of simulations, or if your computer has
limited memory this is probably the script you want to use.


Figure 7B

In directory FIG7B/ run the following matlab scripts to create the 3D
visualisation of the network.

makeNetworkVis27PrimMARKED.m



Figure 7C

In directory FIG7AC/ run the following matlab scripts

runLARGEFSwithShiftingCorr.m
read125FSshiftCorrTHROWAWAYDATA.m
makeShiftCorrPlot125FS.m






Figure 7D

In directory FIG7D/ run the following matlab scripts to create the figure

runLARGEAllUpstateOnlyPrimWrappedNGJscan.m
runLARGEAllUpstateOnlySecWrappedNGJscan.m

readLARGEnetOnlyPrimWrappedNGJ.m
plotLARGEFSNETcrossCorrelogram.m
readLARGEnetOnlySecWrappedNGJ.m
plotLARGEFSNETcrossCorrelogram.m
plotLARGEFSNETcrossCorrelogramMERGEDupdatedFig7D.m