Thalamic neuron: Modeling rhythmic neuronal activity (Meuth et al. 2005)

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Accession:121600
The authors use an in vitro cell model of a single acutely isolated thalamic neuron in the NEURON simulation environment to address and discuss questions in an undergraduate course. Topics covered include passive electrical properties, composition of action potentials, trains of action potentials, multicompartment modeling, and research topics. The paper includes detailed instructions on how to run the simulations in the appendix.
Reference:
1 . Meuth P, Meuth SG, Jacobi D, Broicher T, Pape HC, Budde T (2005) Get the rhythm: modeling neuronal activity. J Undergrad Neurosci Educ 4:A1-A11 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Thalamus geniculate nucleus/lateral principal GLU cell;
Channel(s): I Na,t; I L high threshold; I T low threshold; I A; I K; I h;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Bursting; Tutorial/Teaching; Action Potentials;
Implementer(s):
Search NeuronDB for information about:  Thalamus geniculate nucleus/lateral principal GLU cell; I Na,t; I L high threshold; I T low threshold; I A; I K; I h;
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MeuthEtAl2005_local
model
mechanism
HH.mod *
ia.mod *
ic.mod *
ih.mod *
il.mod *
inap.mod *
it.mod *
leak.mod *
                            
TITLE persistent sodium current 

COMMENT Equations from 
   Golomb D, Amitai Y (1997) Propagating neuronal discharges in
   neocortical slices: computational and experimental study. J Neurophys
   78: 1199-1211.

>< Time constants given at 36 degC.
>< Written by Arthur Houweling.
ENDCOMMENT

NEURON {
        SUFFIX iNaP
        USEION na READ ena WRITE ina 
        RANGE g, ina
}

UNITS {
	(S)  = (siemens)
        (mA) = (milliamp)
        (mV) = (millivolt)
}

PARAMETER {
        g= 7e-5	(S/cm2)
}

ASSIGNED {
        v	(mV)
	ena	(mV)
        ina	(mA/cm2)
	minf
}

BREAKPOINT { 
	rates()
	ina= g* minf* (v- ena) 
}

INITIAL { 
	rates() 
}

PROCEDURE rates() { UNITSOFF
	minf= 1/ (1+ exp(-(v+ 40)/ 5))
} UNITSON