MicrocircuitDB: Synaptic integration in tuft dendrites of layer 5 pyramidal neurons (Larkum et al. 2009)

Synaptic integration in tuft dendrites of layer 5 pyramidal neurons (Larkum et al. 2009)

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Accession:124043

Simulations used in the paper. Voltage responses to current injections in different tuft locations; NMDA and calcium spike generation. Summation of multiple input distribution.
Reference:
1 . Larkum ME, Nevian T, Sandler M, Polsky A, Schiller J (2009) Synaptic integration in tuft dendrites of layer 5 pyramidal neurons: a new unifying principle. Science 325:756-60 [PubMed]

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Model Type:	Neuron or other electrically excitable cell; Synapse; Dendrite;
Brain Region(s)/Organism:
Cell Type(s):	Neocortex L5/6 pyramidal GLU cell;
Channel(s):	I L high threshold; I p,q; I A; I K,leak; I K,Ca; I Sodium;
Gap Junctions:
Receptor(s):	GabaA; AMPA; NMDA;
Gene(s):
Transmitter(s):	Gaba; Glutamate;
Simulation Environment:	NEURON;
Model Concept(s):	Dendritic Action Potentials; Active Dendrites; Detailed Neuronal Models; Synaptic Integration;
Implementer(s):	Polsky, Alon [alonpol at tx.technion.ac.il];