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Dentate gyrus (Morgan et al. 2007, 2008, Santhakumar et al. 2005, Dyhrfjeld-Johnsen et al. 2007)
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Accession:
124513
This model was implemented by Rob Morgan in the Soltesz lab at UC Irvine. It is a scaleable model of the rat dentate gyrus including four cell types. This model runs in serial (on a single processor) and has been published at the size of 50,000 granule cells (with proportional numbers of the other cells).
Reference:
1 .
Santhakumar V, Aradi I, Soltesz I (2005) Role of mossy fiber sprouting and mossy cell loss in hyperexcitability: a network model of the dentate gyrus incorporating cell types and axonal topography.
J Neurophysiol
93
:437-53
[
PubMed
]
2 .
Dyhrfjeld-Johnsen J, Santhakumar V, Morgan RJ, Huerta R, Tsimring L, Soltesz I (2007) Topological determinants of epileptogenesis in large-scale structural and functional models of the dentate gyrus derived from experimental data.
J Neurophysiol
97
:1566-87
[
PubMed
]
3 .
Morgan RJ, Soltesz I (2008) Nonrandom connectivity of the epileptic dentate gyrus predicts a major role for neuronal hubs in seizures.
Proc Natl Acad Sci U S A
105
:6179-84
[
PubMed
]
4 .
Morgan RJ, Santhakumar V, Soltesz I (2007) Modeling the dentate gyrus.
Prog Brain Res
163
:639-58
[
PubMed
]
Citations
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Model Information
(Click on a link to find other models with that property)
Model Type:
Realistic Network;
Brain Region(s)/Organism:
Dentate gyrus;
Cell Type(s):
Dentate gyrus granule GLU cell;
Dentate gyrus mossy cell;
Dentate gyrus basket cell;
Dentate gyrus hilar cell;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
Model Concept(s):
Epilepsy;
Implementer(s):
Bezaire, Marianne [mariannejcase at gmail.com];
Morgan, Robert [polomav at gmail.com];
Search NeuronDB
for information about:
Dentate gyrus granule GLU cell
;
Files displayed below are from the
corrected
original
implementation
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dentate_gyrus
500net
README.html
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Effects of increasing CREB on storage and recall processes in a CA1 network (Bianchi et al. 2014)
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
Parallel network simulations with NEURON (Migliore et al 2006)
State dependent drug binding to sodium channels in the dentate gyrus (Thomas & Petrou 2013)
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Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
Parallel network simulations with NEURON (Migliore et al 2006)
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Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Dentate gyrus network model (Santhakumar et al 2005)
Dentate gyrus network model (Tejada et al 2014)
Effects of increasing CREB on storage and recall processes in a CA1 network (Bianchi et al. 2014)
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
Parallel network simulations with NEURON (Migliore et al 2006)
State dependent drug binding to sodium channels in the dentate gyrus (Thomas & Petrou 2013)
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Parallel network simulations with NEURON (Migliore et al 2006)
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screenshot.jpg
4 0.00469364200 0.0054048 0.025588 0.15642
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