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A Fast Rhythmic Bursting Cell: in vivo cell modeling (Lee 2007)
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Accession:
125857
One of the cellular mechanisms underlying the generation of gamma oscillations is a type of cortical pyramidal neuron named fast rhythmic bursting (FRB) cells. After cells from cats' primary visual cortices were filled with Neurobiotin, the brains were cut, and the cells were photographed. One FRB cell was chosen to be confocaled, reconstructed with Neurolucida software, and generated a detailed multi-compartmental model in the NEURON program. We explore firing properties of FRB cells and the role of enhanced Na+ conductance.
Reference:
1 .
Lee, J (2007) Fast Rhythmic Bursting Cells: The Horizontal Fiber System in the Cat’s Primary Visual Cortex
Penn McNair Research Journal
1(1)
:1
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Model Information
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Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Neocortex;
Cell Type(s):
Channel(s):
I Na,p;
I Na,t;
I K,Ca;
I Sodium;
I Calcium;
I Potassium;
I_Na,Ca;
I_K,Na;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Glutamate;
Simulation Environment:
NEURON;
Model Concept(s):
Activity Patterns;
Bursting;
Spatio-temporal Activity Patterns;
Action Potentials;
Vision;
Implementer(s):
Lee, Jin [jin3 at sas.upenn.edu];
Search NeuronDB
for information about:
I Na,p
;
I Na,t
;
I K,Ca
;
I Sodium
;
I Calcium
;
I Potassium
;
I_Na,Ca
;
I_K,Na
;
Glutamate
;
Download the displayed file
/
FRB
readme.html
cacurrent.mod
cadecay.mod
kaf.mod
kahp.mod
kc.mod
kdr.mod
leak.mod
naf.mod
nap.mod
2FRB.hoc
FRB_12_19.hoc
FRB_12_21.hoc
frb_session.ses
FRB3.hoc
kaf_taum.dat
*
Other models using kaf_taum.dat:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
kaf_vtau.dat
*
Other models using kaf_vtau.dat:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
mosinit.hoc
nap_tauh.dat
*
Other models using nap_tauh.dat:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
nap_vtau.dat
*
Other models using nap_vtau.dat:
Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
Multiscale simulation of the striatal medium spiny neuron (Mattioni & Le Novere 2013)
NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
NlData.BK1
NlData.BK2
screenshot.jpg
screenshot2.jpg
variable_dt.ses
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2FRB
FRB3
FRB_12_19
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