MicrocircuitDB: Regulation of firing frequency in a midbrain dopaminergic neuron model (Kuznetsova et al. 2010)

Regulation of firing frequency in a midbrain dopaminergic neuron model (Kuznetsova et al. 2010)

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Accession:127507

A dopaminergic (DA) neuron model with a morphologicaly realistic dendritic architecture. The model captures several salient features of DA neurons under different pharmacological manipulations and exhibits depolarization block for sufficiently high current pulses applied to the soma.
Reference:
1 . Kuznetsova AY, Huertas MA, Kuznetsov AS, Paladini CA, Canavier CC (2010) Regulation of firing frequency in a computational model of a midbrain dopaminergic neuron. J Comput Neurosci 28:389-403 [PubMed]

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Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:	Basal ganglia;
Cell Type(s):	Substantia nigra pars compacta DA cell;
Channel(s):	I Na,t; I L high threshold; I N; I T low threshold; I A; I K; I K,Ca; Na/K pump;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	NEURON;
Model Concept(s):	Activity Patterns; Temporal Pattern Generation; Oscillations;
Implementer(s):	Huertas, Marco [huertas.marco at gmail.com];