"Windup is characterized as a frequency-dependent
increase in the number of evoked action potentials in dorsal
horn neurons in response to electrical stimulation of afferent C-fibers.
The approach presented here relies on mathematical and
computational analysis to study the mechanism(s) underlying windup.
From experimentally obtained windup profiles, we extract the time
scale of the facilitation mechanisms that may support the characteristics
Guided by these values and using simulations of a
biologically realistic compartmental model of a wide dynamic range
(WDR) neuron, we are able to assess the contribution of each
mechanism for the generation of action potentials windup.
Aguiar P, Sousa M, Lima D (2010) NMDA channels together with L-type calcium currents and calcium-activated nonspecific cationic currents are sufficient to generate windup in WDR neurons. J Neurophysiol 104:1155-66 [PubMed]
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