Intracortical synaptic potential modulation by presynaptic somatic potential (Shu et al. 2006, 2007)

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Accession:135787
" ... Here we show that the voltage fluctuations associated with dendrosomatic synaptic activity propagate significant distances along the axon, and that modest changes in the somatic membrane potential of the presynaptic neuron modulate the amplitude and duration of axonal action potentials and, through a Ca21- dependent mechanism, the average amplitude of the postsynaptic potential evoked by these spikes. These results indicate that synaptic activity in the dendrite and soma controls not only the pattern of action potentials generated, but also the amplitude of the synaptic potentials that these action potentials initiate in local cortical circuits, resulting in synaptic transmission that is a mixture of triggered and graded (analogue) signals."
Reference:
1 . Shu Y, Duque A, Yu Y, Haider B, McCormick DA (2007) Properties of action-potential initiation in neocortical pyramidal cells: evidence from whole cell axon recordings. J Neurophysiol 97:746-60 [PubMed]
2 . Shu Y, Hasenstaub A, Duque A, Yu Y, McCormick DA (2006) Modulation of intracortical synaptic potentials by presynaptic somatic membrane potential. Nature 441:761-5 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Axon;
Brain Region(s)/Organism:
Cell Type(s): Neocortex L5/6 pyramidal GLU cell;
Channel(s): I Na,t; I L high threshold; I A; I K; I M; I h; I K,Ca; I_AHP; I_KD;
Gap Junctions:
Receptor(s): GabaA; AMPA; NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Detailed Neuronal Models; Action Potentials; Synaptic Integration;
Implementer(s):
Search NeuronDB for information about:  Neocortex L5/6 pyramidal GLU cell; GabaA; AMPA; NMDA; I Na,t; I L high threshold; I A; I K; I M; I h; I K,Ca; I_AHP; I_KD;
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ShuEtAl20062007
readme.txt
ampa5.mod *
ca.mod *
cad.mod
caL3d.mod *
capump.mod
gabaa5.mod *
Gfluct.mod *
ia.mod *
iahp.mod *
iahp2.mod *
ih.mod
im.mod *
kca.mod *
km.mod *
kv.mod *
na.mod *
NMDA_Mg.mod *
nmda5.mod *
release.mod *
2006_Nature.pdf
2006_Nature_supp.pdf
best_full_axon_decay.hoc
best_full_axon_spike_init.hoc
decay_constant.gif
for_decay.m
for_initiation.m
j4a.hoc *
j4a_removedendrite.hoc
j4a_removedendrite1.hoc
j7.hoc *
j8.hoc *
j8_removedendrite.hoc
lcAS3.hoc *
mosinit.hoc
spike_initiation.gif
                            
/*
Aspiny layer 3 cortical neuron

B. Connors and L. Cauller
Please contact the authors for details or for permission to use this 
morphology in your publication.

*/

{ dArea=0   shrink=.1 tipseg=.5
  napath=46 ndend0=15 ndend1=36 ndend2=4 ndend3=14 ndend4=4 ndend5=2 \
  ndend6=13 natips=33 nbtips=0 naotips=0 	nexus=napath-1}

aspiny=1

create soma, sapath, s, leakyseal, dend0[ndend0], dend1[22],\
	dend2[ndend2], dend3[ndend3], dend4[ndend4], \
	dend5[ndend5], dend6[ndend6], apath[napath], atip[natips]

forall {nseg=2 diam= .1 L=.1}

sapath    {nseg=2 diam=5.6  L= 4.1 }
soma      {nseg=2 diam=13.2 L= 8.2  }
s         {nseg=2 diam=3.3  L= 4.1 }
leakyseal {nseg=1 diam=10   L=.1  }
dend0[0]  {nseg=2 diam= 1.54  L= 3.380015  }
dend0[1]  {nseg=2 diam= 1.2  L= 8.406831  }
dend0[2]  {nseg=2 diam= .86  L= 4.09196  }
dend0[3]  {nseg=2 diam= .52  L= 48.88392  }
dend0[4]  {nseg=2 diam= .2  L= 16.67353  }
dend0[5]  {nseg=2 diam= .2  L= 30.79526  }
dend0[6]  {nseg=2 diam= .52  L= 20.4368  }
dend0[7]  {nseg=2 diam= .2  L= 57.21962  }
dend0[8]  {nseg=2 diam= .86  L= 8.50969  }
dend0[9]  {nseg=2 diam= .52  L= 15.67022  }
dend0[10]  {nseg=2 diam= .2  L= 92.44191  }
dend0[11]  {nseg=2 diam= 1.2  L= 2.937312  }
dend0[12]  {nseg=2 diam= .86  L= 1.234221  }
dend0[13]  {nseg=2 diam= .52  L= 56.71727  }
dend0[14]  {nseg=2 diam= .2  L= 79.65829  }
apath[0]  {nseg=2 diam= 5.66  L= 3.483487  }
apath[1]  {nseg=2 diam= 2.24  L= 3.036067  }
apath[2]  {nseg=2 diam= 1.88  L= 8.701141  }
apath[3]  {nseg=2 diam= 1.88  L= 3.223197  }
apath[4]  {nseg=2 diam= 1.88  L= 3.639464  }
apath[5]  {nseg=2 diam= 1.54  L= 4.751868  }
apath[6]  {nseg=2 diam= 1.54  L= 6.23092  } /*dend1[6]*/
apath[7]  {nseg=2 diam= 1.54  L= 10.0  } /*6*/
apath[8]  {nseg=2 diam= 1.2  L= 10.0  } /* dend1[7]*/
apath[9]  {nseg=2 diam= 1.2  L= 3.1601  } /*7*/
apath[10] {nseg=2 diam= 1.2  L= 8.052281  }/* dend1[8]*/
apath[11] {nseg=2 diam= .86  L= 3.75661  } /*dend1[9]
apath[12] {nseg=2 diam= .86  L= 10.00  } /*9*/
apath[13] {nseg=2 diam= .86  L= 10.00  } /*9*/
apath[14] {nseg=2 diam= .86  L= 10.00  } /*9*/
apath[15] {nseg=2 diam= .86  L= 10.00  } /*9*/
apath[16]  {nseg=2 diam= .86  L= 10.1887  } /*dend1[10] */
for  i=17,32 {apath[i] {nseg=2 diam=.86  L=10}} /*10*/
apath[33]  {nseg=2 diam= .86  L= 3.49696  } /*11*/
apath[34]  {nseg=2 diam= .86  L= 10  }  /*11*/
apath[35]  {nseg=2 diam= .52  L= 10.74542  }/*12*/
apath[36]  {nseg=2 diam= .52  L= 10.0  }/*12*/

for i=37,44 {apath[i]  {nseg=2 diam= .2  L= 10 }} /*13*/
apath[45]  {nseg=2 diam= .2  L= 4.48232  } /*13*/

dend1[0]  {nseg=2 diam= .2  L= 51.45483  }
dend1[1]  {nseg=2 diam= .2  L= 2.104204  }
dend1[2]  {nseg=2 diam= .2  L= 4.944441  }
dend1[3]  {nseg=2 diam= .2  L= 26.68225  }
dend1[4]  {nseg=2 diam= .2  L= 9.444315  }
dend1[5]  {nseg=2 diam= .2  L= 11.89076  }
dend1[6]  {nseg=2 diam= .2  L= 103.429  }
dend1[7]  {nseg=2 diam= .2  L= 16.73799  }
dend1[8]  {nseg=2 diam= .2  L= 2.700927  }
dend1[9]  {nseg=2 diam= .2  L= 21.31327  }
dend1[10]  {nseg=2 diam= .2  L= 17.1893  }
dend1[11]  {nseg=2 diam= .2  L= 21.14153  }
dend1[12]  {nseg=2 diam= .86  L= 18.09393  }
dend1[13]  {nseg=2 diam= .52  L= 96.90914  }
dend1[14]  {nseg=2 diam= .2  L= 51.8471  }
dend1[15]  {nseg=2 diam= .52  L= 70.11376  }
dend1[16]  {nseg=2 diam= .2  L= 40.60686  }
dend1[17]  {nseg=2 diam= .2  L= 111.8526  }
dend1[18]  {nseg=2 diam= .86  L= 16.84019  }
dend1[19]  {nseg=2 diam= .52  L= 8.971144  }
dend1[20]  {nseg=2 diam= .2  L= 10.0097  }
dend1[21]  {nseg=2 diam= .2  L= 152.0742  }
dend2[0]  {nseg=2 diam= 1.54  L= 15.43236  }
dend2[1]  {nseg=2 diam= 1.2  L= 17.35308  }
dend2[2]  {nseg=2 diam= .52  L= 150.022  }
dend2[3]  {nseg=2 diam= .52  L= 43.15767  }
dend3[0]  {nseg=2 diam= 3.26  L= 4.192989  }
dend3[1]  {nseg=2 diam= .2  L= 17.92507  }
dend3[2]  {nseg=2 diam= 1.88  L= 12.07538  }
dend3[3]  {nseg=2 diam= 1.54  L= 5.903541  }
dend3[4]  {nseg=2 diam= 1.2  L= 14.12161  }
dend3[5]  {nseg=2 diam= 1.2  L= 86.32748  }
dend3[6]  {nseg=2 diam= .2  L= 92.38025  }
dend3[7]  {nseg=2 diam= .2  L= 7.08552  }
dend3[8]  {nseg=2 diam= .86  L= 16.17919  }
dend3[9]  {nseg=2 diam= .86  L= 2.070484  }
dend3[10]  {nseg=2 diam= .52  L= 88.66397  }
dend3[11]  {nseg=2 diam= .2  L= 66.17597  }
dend3[12]  {nseg=2 diam= .52  L= 104.1001  }
dend3[13]  {nseg=2 diam= .2  L= 61.90701  }
dend4[0]  {nseg=2 diam= 1.2  L= 15.86683  }
dend4[1]  {nseg=2 diam= .86  L= 22.17022  }
dend4[2]  {nseg=2 diam= .86  L= 37.45369  }
dend4[3]  {nseg=2 diam= .86  L= 5.749932  }
dend5[0]  {nseg=2 diam= .52  L= 96.16141  }
dend5[1]  {nseg=2 diam= .2  L= 51.23716  }
dend6[0]  {nseg=2 diam= .86  L= 9.968356  }
dend6[1]  {nseg=2 diam= .86  L= 2.258961  }
dend6[2]  {nseg=2 diam= .52  L= 5.679591  }
dend6[3]  {nseg=2 diam= .52  L= 33.11613  }
dend6[4]  {nseg=2 diam= .52  L= 9.515333  }
dend6[5]  {nseg=2 diam= .2  L= 65.53345  }
dend6[6]  {nseg=2 diam= .2  L= 48.7303  }
dend6[7]  {nseg=2 diam= .2  L= 108.399  }
dend6[8]  {nseg=2 diam= .2  L= 45.64591  }
dend6[9]  {nseg=2 diam= .2  L= 7.826734  }
dend6[10]  {nseg=2 diam= .2  L= 54.01116  }
dend6[11]  {nseg=2 diam= .2  L= 93.49458  }
dend6[12]  {nseg=2 diam= .2  L= 53.43756  }

for i=0,napath-2 { apath[i] connect apath[i+1] (0), 1}

sapath { connect apath[0] (0), 1
          connect soma    (0), 0}
soma   {connect s        (0),1 
	connect dend0[0] (0), .5
	connect leakyseal (0),.5
	connect dend2[0] (0), .5
	connect dend4[0] (0), .5
	connect dend5[0] (0), .5
	connect dend6[0] (0), .5}
s	connect dend3[0] (0), 1

dend0[0] {connect dend0[1]  (0), 1
          connect dend0[11]  (0), 1}
dend0[1] {connect dend0[2]  (0), 1
          connect dend0[8]  (0), 1}
dend0[2]  connect dend0[3]  (0), 1
dend0[3]  connect dend0[4]  (0), 1
dend0[4] {connect dend0[5]  (0), 1
          connect dend0[6]  (0), 1}
dend0[6]  connect dend0[7]  (0), 1
dend0[8]  connect dend0[9]  (0), 1
dend0[9]  connect dend0[10]  (0), 1
dend0[11]  connect dend0[12]  (0), 1
dend0[12]  connect dend0[13]  (0), 1
dend0[13]  connect dend0[14]  (0), 1
apath[2]   connect dend1[21]  (0), 1
apath[3]   connect dend1[18]  (0), 1
apath[4]   connect dend1[17]  (0), 1
apath[5]   connect dend1[15]  (0), 1
apath[9]   connect dend1[12]  (0), 1
apath[10]  connect dend1[9]  (0), 1
apath[15]  connect dend1[6]  (0), 1
apath[32]  connect dend1[1]  (0), 1
apath[34]  connect dend1[0]  (0), 1

dend1[1] {connect dend1[2]  (0), 1
           connect dend1[3]  (0), 1}
dend1[3] {connect dend1[4]  (0), 1
           connect dend1[5]  (0), 1}
dend1[6] {connect dend1[7]  (0), 1
           connect dend1[8]  (0), 1}
dend1[9] {connect dend1[10]  (0), 1
           connect dend1[11]  (0), 1}
dend1[12]  connect dend1[13]  (0), 1
dend1[13]  connect dend1[14]  (0), 1
dend1[15]  connect dend1[16]  (0), 1
dend1[18]  connect dend1[19]  (0), 1
dend1[19]  connect dend1[20]  (0), 1
dend2[0]  connect dend2[1]  (0), 1
dend2[1] {connect dend2[2]  (0), 1
          connect dend2[3]  (0), 1}
dend3[0] {connect dend3[1]  (0), 1
          connect dend3[2]  (0), 1}
dend3[2] {connect dend3[3]  (0), 1
          connect dend3[8]  (0), 1}
dend3[3]  connect dend3[4]  (0), 1
dend3[4] {connect dend3[5]  (0), 1
          connect dend3[7]  (0), 1}
dend3[5]  connect dend3[6]  (0), 1
dend3[8] {connect dend3[9]  (0), 1
          connect dend3[12]  (0), 1}
dend3[9]  connect dend3[10]  (0), 1
dend3[10]  connect dend3[11]  (0), 1
dend3[12]  connect dend3[13]  (0), 1
dend4[0]  connect dend4[1]  (0), 1
dend4[1] {connect dend4[2]  (0), 1
          connect dend4[3]  (0), 1}
dend5[0]  connect dend5[1]  (0), 1
dend6[0] {connect dend6[1]  (0), 1
          connect dend6[8]  (0), 1}
dend6[1]  connect dend6[2]  (0), 1
dend6[2] {connect dend6[3]  (0), 1
          connect dend6[7]  (0), 1}
dend6[3] {connect dend6[4]  (0), 1
          connect dend6[6]  (0), 1}
dend6[4]  connect dend6[5]  (0), 1
dend6[8] {connect dend6[9]  (0), 1
          connect dend6[12]  (0), 1}
dend6[9] {connect dend6[10]  (0), 1
          connect dend6[11]  (0), 1}

/*tip sections*/

dend3[13] connect atip[0](0), tipseg
dend3[11] connect atip[1](0), tipseg
dend3[6] connect atip[2](0), tipseg
dend3[1] connect atip[3](0), tipseg
dend0[14] connect atip[4](0), tipseg
dend0[10] connect atip[5](0), tipseg
dend0[7] connect atip[6](0), tipseg
dend0[5] connect atip[7](0), tipseg
dend2[3] connect atip[8](0), tipseg
dend2[2] connect atip[9](0), tipseg
dend4[3] connect atip[11](0), tipseg
dend4[2] connect atip[12](0), tipseg
dend5[1] connect atip[13](0), tipseg
 dend6[12] connect atip[14](0), tipseg
 dend6[11] connect atip[15](0), tipseg
 dend6[10] connect atip[16](0), tipseg
 dend6[7] connect atip[17](0), tipseg
 dend6[6] connect atip[18](0), tipseg
 dend6[5] connect atip[19](0), tipseg
 dend1[21] connect atip[20](0), tipseg
 dend1[20] connect atip[21](0), tipseg
  dend1[17] connect atip[22](0), tipseg
  dend1[16] connect atip[23](0), tipseg
  dend1[14] connect atip[24](0), tipseg
  dend1[11] connect atip[25](0), tipseg
  dend1[10] connect atip[26](0), tipseg
  dend1[8] connect atip[27](0), tipseg
  dend1[7] connect atip[28](0), tipseg
  dend1[5] connect atip[29](0), tipseg
  dend1[4] connect atip[30](0), tipseg
  dend1[2] connect atip[31](0), tipseg
  dend1[0] connect atip[32](0), tipseg
  apath[45] connect atip[10](0), tipseg


double pdend0[ndend0], pdend1[ndend1], pdend2[ndend2], \
	pdend3[ndend3], pdend4[ndend4], pdend5[ndend5], \
	pdend6[ndend6]
   pdend0[0] = 3.380015
   pdend0[1] = 11.78685
   pdend0[2] = 15.87881
   pdend0[3] = 64.76273
   pdend0[4] = 81.43626
   pdend0[5] = 112.2315
   pdend0[6] = 101.8731
   pdend0[7] = 159.0927
   pdend0[8] = 20.29654
   pdend0[9] = 35.96675
   pdend0[10] = 128.4087
   pdend0[11] = 6.317327
   pdend0[12] = 7.551547
   pdend0[13] = 64.26881
   pdend0[14] = 143.9271
   pdend1[0] = 3.483487
   pdend1[1] = 6.519555
   pdend1[2] = 15.2207
   pdend1[3] = 18.44389
   pdend1[4] = 22.08335
   pdend1[5] = 26.83522
   pdend1[6] = 43.06615
   pdend1[7] = 56.22625
   pdend1[8] = 64.27853
   pdend1[9] = 108.0351
   pdend1[10] = 278.2238
   pdend1[11] = 291.7208
   pdend1[12] = 312.4662
   pdend1[13] = 386.9485
   pdend1[14] = 343.1756
   pdend1[15] = 280.328
   pdend1[16] = 285.2725
   pdend1[17] = 307.0103
   pdend1[18] = 316.4546
   pdend1[19] = 318.9011
   pdend1[20] = 211.4641
   pdend1[21] = 228.2021
   pdend1[22] = 214.165
   pdend1[23] = 85.5918
   pdend1[24] = 102.7811
   pdend1[25] = 106.7333
   pdend1[26] = 74.32018
   pdend1[27] = 171.2293
   pdend1[28] = 223.0764
   pdend1[29] = 96.94898
   pdend1[30] = 137.5558
   pdend1[31] = 133.9359
   pdend1[32] = 35.28408
   pdend1[33] = 44.25523
   pdend1[34] = 54.26493
   pdend1[35] = 167.2949
   pdend2[0] = 15.43236
   pdend2[1] = 32.78543
   pdend2[2] = 182.8074
   pdend2[3] = 75.94311
   pdend3[0] = 4.192989
   pdend3[1] = 22.11806
   pdend3[2] = 16.26837
   pdend3[3] = 22.17191
   pdend3[4] = 36.29352
   pdend3[5] = 122.621
   pdend3[6] = 215.0013
   pdend3[7] = 43.37904
   pdend3[8] = 32.44756
   pdend3[9] = 34.51804
   pdend3[10] = 123.182
   pdend3[11] = 189.358
   pdend3[12] = 136.5476
   pdend3[13] = 198.4547
   pdend4[0] = 15.86683
   pdend4[1] = 38.03705
   pdend4[2] = 75.49074
   pdend4[3] = 43.78698
   pdend5[0] = 96.16141
   pdend5[1] = 147.3986
   pdend6[0] = 9.968356
   pdend6[1] = 12.22732
   pdend6[2] = 17.90691
   pdend6[3] = 51.02304
   pdend6[4] = 60.53838
   pdend6[5] = 126.0718
   pdend6[6] = 99.75335
   pdend6[7] = 126.306
   pdend6[8] = 55.61427
   pdend6[9] = 63.441
   pdend6[10] = 117.4522
   pdend6[11] = 156.9356
   pdend6[12] = 109.0518

nbranchpoints=9
double bp[nbranchpoints]
bp[0]=15.2
bp[1]=3.22
bp[2]=3.64
bp[3]=4.75
bp[4]=29.39
bp[5]=8.05
bp[6]=43.76
bp[7]=170.19
bp[8]=13.5