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AP back-prop. explains threshold variability and rapid rise (McCormick et al. 2007, Yu et al. 2008)
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This simple axon-soma model explained how the rapid rising phase in the somatic spike is derived from the propagated axon initiated spike, and how the somatic spike threshold variance is affected by spike propagation.
McCormick DA, Shu Y, Yu Y (2007) Neurophysiology: Hodgkin and Huxley model--still standing?
:E1-2; discussion E2-3
Yu Y, Shu Y, McCormick DA (2008) Cortical action potential backpropagation explains spike threshold variability and rapid-onset kinetics.
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Neuron or other electrically excitable cell;
Neocortex L5/6 pyramidal GLU cell;
Neocortex L2/3 pyramidal GLU cell;
I L high threshold;
I T low threshold;
Action Potential Initiation;
Detailed Neuronal Models;
for information about:
Neocortex L5/6 pyramidal GLU cell
Neocortex L2/3 pyramidal GLU cell
I L high threshold
I T low threshold
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