Biophysically realistic neural modeling of the MEG mu rhythm (Jones et al. 2009)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:136803
"Variations in cortical oscillations in the alpha (7–14 Hz) and beta (15–29 Hz) range have been correlated with attention, working memory, and stimulus detection. The mu rhythm recorded with magnetoencephalography (MEG) is a prominent oscillation generated by Rolandic cortex containing alpha and beta bands. Despite its prominence, the neural mechanisms regulating mu are unknown. We characterized the ongoing MEG mu rhythm from a localized source in the finger representation of primary somatosensory (SI) cortex. Subjects showed variation in the relative expression of mu-alpha or mu-beta, which were nonoverlapping for roughly 50% of their respective durations on single trials. To delineate the origins of this rhythm, a biophysically principled computational neural model of SI was developed, with distinct laminae, inhibitory and excitatory neurons, and feedforward (FF, representative of lemniscal thalamic drive) and feedback (FB, representative of higher-order cortical drive or input from nonlemniscal thalamic nuclei) inputs defined by the laminar location of their postsynaptic effects. ..."
Reference:
1 . Jones SR, Pritchett DL, Sikora MA, Stufflebeam SM, Hämäläinen M, Moore CI (2009) Quantitative analysis and biophysically realistic neural modeling of the MEG mu rhythm: rhythmogenesis and modulation of sensory-evoked responses. J Neurophysiol 102:3554-72 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Neocortex L5/6 pyramidal GLU cell; Neocortex L2/3 pyramidal GLU cell;
Channel(s): I Na,t; I T low threshold; I K; I h;
Gap Junctions:
Receptor(s): GabaA; GabaB; AMPA; NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Touch;
Implementer(s):
Search NeuronDB for information about:  Neocortex L5/6 pyramidal GLU cell; Neocortex L2/3 pyramidal GLU cell; GabaA; GabaB; AMPA; NMDA; I Na,t; I T low threshold; I K; I h;
/
JonesEtAl2009
mod_files
ar.mod
ca.mod *
cad.mod
cat.mod
dipole.mod
kca.mod
km.mod *
pp_dipole.mod
                            
NEURON {
: SUFFIX dipole
POINT_PROCESS Dipole
RANGE ri, ia, Q, ztan
POINTER pv

: POINTER Qsum : for density. sums into Dipole at section position 1
RANGE Qsum : for POINT_PROCESS. Gets additions from dipole
POINTER Qtotal : to allow Vector record of total in a process
}

UNITS {
	(nA) = (nanoamp)
	(mV) =(millivolt)
	(Mohm) = (megaohm)
	(um) = (micrometer)
	(Am) = (amp meter)
	(fAm) = (femto amp meter)
}

ASSIGNED {
	ia (nA)
	ri (Mohm)
	pv (mV)
	v (mV)
	ztan (um)
	Q  (fAm)
	Qsum (fAm)
	Qtotal (fAm)
}

AFTER SOLVE {     	: solve for v's first then use them
	ia=(pv-v)/ri
	Q=ia*ztan
	Qsum = Qsum + Q
	Qtotal = Qtotal + Q
}
	
AFTER INITIAL {
	ia=(pv-v)/ri
	Q=ia*ztan
	Qsum = Qsum + Q
	Qtotal = Qtotal + Q
}

: following needed for POINT_PROCESS only but will work if also in SUFFIX
 BEFORE INITIAL {
	Qsum = 0
	Qtotal = 0
 }
 BEFORE BREAKPOINT {
	Qsum = 0
	Qtotal = 0
 }