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Ketamine disrupts theta modulation of gamma in a computer model of hippocampus (Neymotin et al 2011)
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"Abnormalities in oscillations have been suggested to play a role in schizophrenia. We studied theta-modulated gamma oscillations in a computer model of hippocampal CA3 in vivo with and without simulated application of ketamine, an NMDA receptor antagonist and psychotomimetic. Networks of 1200 multi-compartment neurons (pyramidal, basket and oriens-lacunosum moleculare, OLM, cells) generated theta and gamma oscillations from intrinsic network dynamics: basket cells primarily generated gamma and amplified theta, while OLM cells strongly contributed to theta. ..."
Neymotin SA, Lazarewicz MT, Sherif M, Contreras D, Finkel LH, Lytton WW (2011) Ketamine Disrupts Theta Modulation of Gamma in a Computer Model of Hippocampus
J Neurosci .
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Hippocampus CA3 pyramidal GLU cell;
Hippocampus CA3 interneuron basket GABA cell;
Hippocampus CA3 stratum oriens lacunosum-moleculare interneuron;
I L high threshold;
Lazarewicz, Maciej [mlazarew at gmu.edu];
Neymotin, Sam [Samuel.Neymotin at nki.rfmh.org];
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Hippocampus CA3 pyramidal GLU cell
Hippocampus CA3 interneuron basket GABA cell
I L high threshold
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