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Realistic Microcircuits
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Engaging distinct oscillatory neocortical circuits (Vierling-Claassen et al. 2010)
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Accession:
141273
"Selective optogenetic drive of fast-spiking (FS) interneurons (INs) leads to enhanced local field potential (LFP) power across the traditional “gamma” frequency band (20–80 Hz; Cardin et al., 2009). In contrast, drive to regular-spiking (RS) pyramidal cells enhances power at lower frequencies, with a peak at 8 Hz. The first result is consistent with previous computational studies emphasizing the role of FS and the time constant of GABAA synaptic inhibition in gamma rhythmicity. However, the same theoretical models do not typically predict low-frequency LFP enhancement with RS drive. To develop hypotheses as to how the same network can support these contrasting behaviors, we constructed a biophysically principled network model of primary somatosensory neocortex containing FS, RS, and low-threshold spiking (LTS) INs. ..."
Reference:
1 .
Vierling-Claassen D, Cardin JA, Moore CI, Jones SR (2010) Computational modeling of distinct neocortical oscillations driven by cell-type selective optogenetic drive: separable resonant circuits controlled by low-threshold spiking and fast-spiking interneurons.
Front Hum Neurosci
4
:198
[
PubMed
]
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Model Information
(Click on a link to find other models with that property)
Model Type:
Realistic Network;
Brain Region(s)/Organism:
Neocortex;
Cell Type(s):
Neocortex L2/3 pyramidal GLU cell;
Neocortex fast spiking (FS) interneuron;
Neocortex spiking regular (RS) neuron;
Neocortex spiking low threshold (LTS) neuron;
Channel(s):
I Na,t;
I T low threshold;
I K;
I M;
I h;
I K,Ca;
I Calcium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
Model Concept(s):
Oscillations;
Detailed Neuronal Models;
Brain Rhythms;
Evoked LFP;
Touch;
Implementer(s):
Vierling-Claassen, Dorea ;
Search NeuronDB
for information about:
Neocortex L2/3 pyramidal GLU cell
;
I Na,t
;
I T low threshold
;
I K
;
I M
;
I h
;
I K,Ca
;
I Calcium
;
/
Vierling-ClaassenEtAl2010
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