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Hippocampal CA3 network and circadian regulation (Stanley et al. 2013)
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This model produces the hippocampal CA3 neural network model used in the paper below. It has two modes of operation, a default mode and a circadian mode. In the circadian mode, parameters are swept through a range of values. This model can be quite easily adapted to produce theta and gamma oscillations, as certain parameter sweeps will reveal (see Figures). BASH scripts interact with GENESIS 2.3 to implement parameter sweeps. The model contains four cell types derived from prior papers. CA3 pyramidal are derived from Traub et al (1991); Basket, stratum oriens (O-LM), and Medial Septal GABAergic (MSG) interneurons are taken from Hajos et al (2004).
Stanley DA, Talathi SS, Parekh MB, Cordiner DJ, Zhou J, Mareci TH, Ditto WL, Carney PR (2013) Phase shift in the 24-hour rhythm of hippocampal EEG spiking activity in a rat model of temporal lobe epilepsy.
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Neuron or other electrically excitable cell;
Hippocampus CA3 pyramidal GLU cell;
Hippocampus CA3 interneuron basket GABA cell;
Hippocampus CA3 stratum oriens lacunosum-moleculare interneuron;
Hippocampus septum medial GABAergic neuron;
Stanley, David A ;
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Hippocampus CA3 pyramidal GLU cell
Hippocampus CA3 interneuron basket GABA cell
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