MicrocircuitDB: Layer V PFC pyramidal neuron used to study persistent activity (Sidiropoulou & Poirazi 2012)

Layer V PFC pyramidal neuron used to study persistent activity (Sidiropoulou & Poirazi 2012)

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Accession:144089

"... Here, we use a compartmental modeling approach to search for discriminatory features in the properties of incoming stimuli to a PFC pyramidal neuron and/or its response that signal which of these stimuli will result in persistent activity emergence. Furthermore, we use our modeling approach to study cell-type specific differences in persistent activity properties, via implementing a regular spiking (RS) and an intrinsic bursting (IB) model neuron. ... Collectively, our results pinpoint to specific features of the neuronal response to a given stimulus that code for its ability to induce persistent activity and predict differential roles of RS and IB neurons in persistent activity expression. "
Reference:
1 . Sidiropoulou K, Poirazi P (2012) Predictive features of persistent activity emergence in regular spiking and intrinsic bursting model neurons. PLoS Comput Biol 8:e1002489 [PubMed]

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Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):	Neocortex L5/6 pyramidal GLU cell;
Channel(s):	I Na,p; I Na,t; I L high threshold; I A; I K; I K,Ca; I CAN;
Gap Junctions:
Receptor(s):	GabaA; GabaB; AMPA; NMDA; IP3;
Gene(s):
Transmitter(s):	Gaba; Glutamate;
Simulation Environment:	NEURON;
Model Concept(s):	Activity Patterns; Detailed Neuronal Models;
Implementer(s):	Sidiropoulou, Kyriaki [sidirop at imbb.forth.gr];