Cortical pyramidal neuron, phase response curve (Stiefel et al 2009)

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Accession:144372
Three models of increasing complexity all showing a switch from type II (biphasic) to type I (monophasic) phase response curves with a cholinergic down-modulation of K+ conductances.
Reference:
1 . Stiefel KM, Gutkin BS, Sejnowski TJ (2009) The effects of cholinergic neuromodulation on neuronal phase-response curves of modeled cortical neurons. J Comput Neurosci 26:289-301 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type:
Brain Region(s)/Organism:
Cell Type(s): Neocortex L2/3 pyramidal GLU cell;
Channel(s): I Na,p; I Na,t; I M;
Gap Junctions:
Receptor(s): Muscarinic;
Gene(s):
Transmitter(s): Acetylcholine;
Simulation Environment: NEURON;
Model Concept(s): Action Potentials;
Implementer(s): Stiefel, Klaus [stiefel at salk.edu];
Search NeuronDB for information about:  Neocortex L2/3 pyramidal GLU cell; Muscarinic; I Na,p; I Na,t; I M; Acetylcholine;
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StiefelEtAl2009
README.txt
ca.mod *
cacum.mod
cad.mod *
H.mod
iahp2.mod *
il.mod *
im.mod *
KA.mod
kca.mod *
Kdr.mod
km.mod *
Ks.mod
kv.mod *
Na.mod *
NaP.mod
cell.ses
displayshape.hoc
fig4A.hoc
fig4A_new.hoc
fig5A.hoc
fig5B.hoc
fig5C.hoc
gui.hoc
j8.hoc *
ksprc.ses
makeIF.hoc
multi.hoc
PRC.hoc
PRCsweep.hoc
PY-golomb_original.hoc
PY-golomb_plus.hoc
PY-golomb_simple.hoc
PyMainen.hoc
single.hoc
single_plus.hoc
single1.ses
surface.hoc
synproxy_cch.hoc
synproxy_sweeps.hoc
                            
COMMENT
	calcium accumulation into a volume of area*depth next to the
	membrane with a decay (time constant tau) to resting level
	given by the global calcium variable cai0_ca_ion
ENDCOMMENT

NEURON {
	SUFFIX cacum
	USEION ca READ ica WRITE cai
	RANGE depth, tau, cai0
}

UNITS {
	(mM) = (milli/liter)
	(mA) = (milliamp)
	F = (faraday) (coulombs)
}

PARAMETER {
	depth = 1 (nm)	: assume volume = area*depth
	tau = 10 (ms)
	cai0 = 50e-6 (mM)	: Requires explicit use in INITIAL
			: block for it to take precedence over cai0_ca_ion
			: Do not forget to initialize in hoc if different
			: from this default.
}

ASSIGNED {
	ica (mA/cm2)
}

STATE {
	cai (mM)
}

INITIAL {
	cai = cai0
}

BREAKPOINT {
	SOLVE integrate METHOD derivimplicit
}

DERIVATIVE integrate {
	cai' = -ica/depth/F/2 * (1e7) + (cai0 - cai)/tau
}