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CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
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Accession:
144490
This is an adaptation of Poirazi et al.'s (2003) CA1 model that is used to measure BAP-induced voltage and calcium signals in spines after simulated Schaffer collateral synapse stimulation. In the model, the peak calcium concentration is highly correlated with soma-synapse distance under a number of physiologically-realistic suprathreshold stimulation regimes and for a range of dendritic morphologies. There are also simulations demonstrating that peak calcium can be used to set up a synaptic democracy in a homeostatic manner, whereby synapses regulate their synaptic strength on the basis of the difference between peak calcium and a uniform target value.
Reference:
1 .
Sterratt DC, Groen MR, Meredith RM, van Ooyen A (2012) Spine calcium transients induced by synaptically-evoked action potentials can predict synapse location and establish synaptic democracy.
PLoS Comput Biol
8
:e1002545
[
PubMed
]
Citations
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Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Hippocampus CA1 pyramidal GLU cell;
Channel(s):
I Na,t;
I L high threshold;
I T low threshold;
I A;
I K;
I M;
I Mixed;
I R;
I_AHP;
Gap Junctions:
Receptor(s):
AMPA;
NMDA;
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
Model Concept(s):
Dendritic Action Potentials;
Synaptic Plasticity;
Implementer(s):
Sterratt, David ;
Groen, Martine R [martine.groen at gmail.com];
Search NeuronDB
for information about:
Hippocampus CA1 pyramidal GLU cell
;
AMPA
;
NMDA
;
I Na,t
;
I L high threshold
;
I T low threshold
;
I A
;
I K
;
I M
;
I Mixed
;
I R
;
I_AHP
;
/
bpap
CA1_multi
mechanism
cad.mod
*
Other models using cad.mod:
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
cagk.mod
*
Other models using cagk.mod:
CA1 network model for place cell dynamics (Turi et al 2019)
CA1 network model: interneuron contributions to epileptic deficits (Shuman et al 2019)
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
cal.mod
*
Other models using cal.mod:
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
calH.mod
*
Other models using calH.mod:
CA1 network model for place cell dynamics (Turi et al 2019)
CA1 network model: interneuron contributions to epileptic deficits (Shuman et al 2019)
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
car.mod
*
Other models using car.mod:
CA1 network model for place cell dynamics (Turi et al 2019)
CA1 network model: interneuron contributions to epileptic deficits (Shuman et al 2019)
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
cat.mod
*
Other models using cat.mod:
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
d3.mod
*
Other models using d3.mod:
Amyloid-beta effects on release probability and integration at CA3-CA1 synapses (Romani et al. 2013)
CA1 pyramidal neuron (Combe et al 2018)
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)
CA1 pyramidal neuron: depolarization block (Bianchi et al. 2012)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Effects of increasing CREB on storage and recall processes in a CA1 network (Bianchi et al. 2014)
Layer V PFC pyramidal neuron used to study persistent activity (Sidiropoulou & Poirazi 2012)
Linear vs non-linear integration in CA1 oblique dendrites (Gómez González et al. 2011)
Modelling reduced excitability in aged CA1 neurons as a Ca-dependent process (Markaki et al. 2005)
The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
gabaa.mod
*
Other models using gabaa.mod:
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
Shaping NMDA spikes by timed synaptic inhibition on L5PC (Doron et al. 2017)
gabab.mod
*
Other models using gabab.mod:
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
glutamate.mod
*
Other models using glutamate.mod:
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
h.mod
*
Other models using h.mod:
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)
MEG of Somatosensory Neocortex (Jones et al. 2007)
hha_old.mod
*
Other models using hha_old.mod:
CA1 network model for place cell dynamics (Turi et al 2019)
CA1 network model: interneuron contributions to epileptic deficits (Shuman et al 2019)
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
hha2.mod
*
Other models using hha2.mod:
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
kadist.mod
*
Other models using kadist.mod:
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
kaprox.mod
*
Other models using kaprox.mod:
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
kca.mod
*
Other models using kca.mod:
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
Spine head calcium in a CA1 pyramidal cell model (Graham et al. 2014)
km.mod
*
Other models using km.mod:
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
Layer V PFC pyramidal neuron used to study persistent activity (Sidiropoulou & Poirazi 2012)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
Synaptic integration in tuft dendrites of layer 5 pyramidal neurons (Larkum et al. 2009)
nap.mod
*
Other models using nap.mod:
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)
nmda.mod
*
Other models using nmda.mod:
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
somacar.mod
*
Other models using somacar.mod:
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
mosinit.hoc.old
*
Other models using mosinit.hoc.old:
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
mosinit.poirazi.hoc
*
Other models using mosinit.poirazi.hoc:
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
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